Gene: NTM

50863
CEPU-1|HNT|IGLON2|NTRI
neurotrimin
protein-coding
11q25
Ensembl:ENSG00000182667 MIM:607938 Vega:OTTHUMG00000066364 UniprotKB:Q9P121
NC_000011.10
PubMed|SNP Mapped
3   ANCO-SNPs
OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.369e-1 (AD)  6.322e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1868534chr11:132224572 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs471677chr11:131957812 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs501050chr11:131939677 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09294095chr11:131630464NTMGene body3.456e-4Alcohol use disorders26763658
cg12079699chr11:131564481NTMGene body4.947e-4Alcohol use disorders26763658
cg15302032chr11:131526811NTM2.150e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIRPA0.92
OGDH0.904
TOM1L20.902
BRINP20.898
TSPAN70.895
GPM6A0.894
GRINA0.894
PTPRA0.893
ABR0.891
VPS110.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.743
OR4F29-0.672
TFPI2-0.415
DPPA4-0.363
OR6C74-0.36
ARHGEF35-0.357
GZMK-0.357
FOLR3-0.356
GADL1-0.355
SPINK8-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTM mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTM mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTM mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTM mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTM mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NTM mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of NTM mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NTM mRNA24449571
D000068180AripiprazoleAripiprazole results in decreased expression of NTM mRNA17868501
D001151ArsenicArsenic results in decreased expression of NTM mRNA25922126
D001151ArsenicArsenic results in increased methylation of NTM gene25922126
C006780bisphenol Abisphenol A results in decreased expression of NTM mRNA25181051
D002104CadmiumCadmium results in decreased expression of NTM mRNA25922126
D002104CadmiumCadmium results in increased methylation of NTM gene25922126
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of NTM promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NTM mRNA17484886
D003561CytarabineCytarabine results in decreased expression of NTM mRNA21198554
D013759Dronabinol[Dronabinol co-treated with Ethanol] results in increased expression of NTM mRNA17618662
D013759DronabinolDronabinol results in increased expression of NTM mRNA17618662
D003907DexamethasoneDexamethasone results in decreased expression of NTM mRNA25047013
D000431Ethanol[Dronabinol co-treated with Ethanol] results in increased expression of NTM mRNA17618662
D000431EthanolEthanol results in increased expression of NTM mRNA17618662
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NTM mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of NTM mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of NTM mRNA19167457
D017313FenretinideFenretinide results in decreased expression of NTM mRNA28973697
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of NTM mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NTM mRNA24796395|2511904
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NTM mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NTM mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NTM mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of NTM mRNA25922126
D009151Mustard GasMustard Gas results in decreased expression of NTM mRNA25102026
D009534NiclosamideNiclosamide results in decreased expression of NTM mRNA26452273
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of NTM mRNA"25510870
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of NTM mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of NTM mRNA25119042
D010634PhenobarbitalPhenobarbital affects the expression of NTM mRNA23091169
D011192Potassium DichromatePotassium Dichromate results in increased expression of NTM mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of NTM mRNA18070364
C017947sodium arsenitesodium arsenite affects the methylation of NTM gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NTM mRNA22574217
D014212TretinoinTretinoin results in decreased expression of NTM mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NTM mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of NTM mRNA26272509
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NTM mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NTM gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NTM mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of NTM mRNA22714537
C025643vinclozolinvinclozolin affects the expression of NTM mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NTM mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21982860  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0008038neuron recognition-TAS7891157  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21958147Clinical significance and antibiotic susceptibilities of nontuberculous mycobacteria from patients in Crete, Greece. (2011 Sep)Gitti ZFuture Microbiol
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics
27007918'"Why me, why now?" Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection. (2016 Mar 23)Lake MABMC Med
23672176[Strategies for Mycobacterium avium complex infection control in Japan: how do they improve the present situation?]. (2013 Mar)Ogawa KKekkaku
21036197NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies. (2011 Jan 15)Pan YProg Neuropsychopharmacol Biol Psychiatry
18326333[A study on clinical features of Mycobacterium kansasii pulmonary disease in women]. (2008 Feb)Kamiya HKekkaku