Gene: SLC25A37

51312
HT015|MFRN|MFRN1|MSC|MSCP|PRO1278|PRO1584|PRO2217
solute carrier family 25 member 37
protein-coding
8p21.2
Ensembl:ENSG00000147454 MIM:610387 Vega:OTTHUMG00000163865 UniprotKB:Q9NYZ2
NC_000008.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.204e-1 (AD)  9.777e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17089358chr8:23553762 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAT30.836
SHC10.836
HDAC70.827
NUP980.802
TBC1D2B0.802
PATL10.796
IL18BP0.793
SERPINB90.791
SBNO20.79
NUP2050.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.434
OR4F29-0.414
CPLX3-0.264
HES5-0.25
MYCNOS-0.237
CRH-0.236
ACY3-0.224
ZNRF4-0.222
SNX22-0.209
ARSF-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SLC25A37 mRNA"26377693
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of SLC25A37 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of SLC25A37 mRNA]"27071940
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC25A37 mRNA"21354444|2890350
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC25A37 mRNA28329830
C0065932-anthramine2-anthramine results in increased expression of SLC25A37 mRNA23038007
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SLC25A37 mRNA12958071
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A37 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A37 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC25A37 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC25A37 gene28458013
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of SLC25A37 mRNA"24160326
D001280AtrazineAtrazine results in increased expression of SLC25A37 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC25A37 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC25A37 mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC25A37 mRNA"19150397|2001819
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SLC25A37 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of SLC25A37 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SLC25A37 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SLC25A37 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of SLC25A37 mRNA26496021
D002110CaffeineCaffeine results in decreased expression of SLC25A37 mRNA20864626
C099555CD 437CD 437 results in decreased expression of SLC25A37 mRNA12958071
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC25A37 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC25A37 mRNA24386269
D003042CocaineCocaine results in increased expression of SLC25A37 mRNA15009677|1671032
D003300Copper[Disulfiram binds to Copper] which results in increased expression of SLC25A37 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of SLC25A37 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of SLC25A37 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of SLC25A37 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of SLC25A37 mRNA19770486
C093628cyproconazolecyproconazole results in increased expression of SLC25A37 mRNA22334560
D003703DemecolcineDemecolcine results in decreased expression of SLC25A37 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SLC25A37 mRNA21266533
D004026DieldrinDieldrin results in increased expression of SLC25A37 mRNA28385952
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of SLC25A37 mRNA24690739
C118739entinostatentinostat results in decreased expression of SLC25A37 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A37 mRNA"27188386
C109476epoxiconazoleepoxiconazole results in increased expression of SLC25A37 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC25A37 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SLC25A37 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC25A37 mRNA28329830
D005485FlutamideFlutamide results in increased expression of SLC25A37 mRNA24136188
D003932HeroinHeroin results in increased expression of SLC25A37 mRNA16710320
C492448ICG 001ICG 001 affects the expression of SLC25A37 mRNA26191083
C410337K 7174K 7174 results in increased expression of SLC25A37 mRNA24086573
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of SLC25A37 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC25A37 mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC25A37 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLC25A37 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLC25A37 mRNA"20188158
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of SLC25A37 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC25A37 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC25A37 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SLC25A37 mRNA19812364
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of SLC25A37 mRNA]"21673326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC25A37 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SLC25A37 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of SLC25A37 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SLC25A37 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC25A37 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SLC25A37 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of SLC25A37 mRNA18301758
D010938Plant OilsPlant Oils results in decreased expression of SLC25A37 mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of SLC25A37 mRNA21334430
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLC25A37 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SLC25A37 mRNA28903501
C045950propiconazolepropiconazole results in increased expression of SLC25A37 mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC25A37 mRNA24780913
C059514resveratrolresveratrol results in increased expression of SLC25A37 mRNA22610192
D012643SeleniumSelenium results in increased expression of SLC25A37 mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of SLC25A37 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC25A37 mRNA19073995
C017947sodium arsenitesodium arsenite affects the expression of SLC25A37 mRNA29319823
C017947sodium arsenitesodium arsenite results in decreased expression of SLC25A37 mRNA22714537
D013629TamoxifenTamoxifen affects the expression of SLC25A37 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of SLC25A37 mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of SLC25A37 mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SLC25A37 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A37 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC25A37 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC25A37 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC25A37 mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of SLC25A37 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC25A37 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SLC25A37 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SLC25A37 mRNA17218384
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SLC25A37 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC25A37 mRNA"26179874
C406224valdecoxibvaldecoxib results in increased expression of SLC25A37 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of SLC25A37 mRNA24935251|2915479
D014638VanadatesVanadates results in increased expression of SLC25A37 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC25A37 gene25560391
D014750VincristineVincristine results in decreased expression of SLC25A37 mRNA23649840
D015032ZincZinc deficiency results in increased expression of SLC25A37 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005381iron ion transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0048250iron import into the mitochondrion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1362409Mitochondrial iron-sulfur cluster biogenesisIEA
R-HSA-1430728MetabolismIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal