Gene: PDE1C

5137
Hcam3|cam-PDE 1C|hCam-3
phosphodiesterase 1C
protein-coding
7p14.3
Ensembl:ENSG00000154678 MIM:602987 Vega:OTTHUMG00000023836 UniprotKB:Q14123
NG_051183.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.692e-1 (AD)  6.927e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11765220chr7:32203748 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs2214783chr7:32043563 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs11770536chr7:31934361 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs13223209chr7:31910150 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTN20.902
SLC22A150.887
KIAA1324L0.878
ZNF5360.875
PXK0.874
CCP1100.87
PLEKHH10.865
DIP2B0.86
LGR50.859
PTPDC10.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7B-0.373
EVC2-0.357
SYPL2-0.351
GJB2-0.349
LYN-0.344
PDZK1IP1-0.338
EYA2-0.336
ADORA2B-0.334
PPP1R3G-0.328
RNF43-0.327

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB09283TrapidilSmall Molecule15421-84-8ApprovedTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDE1C mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDE1C mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDE1C mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDE1C mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDE1C mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of PDE1C mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE1C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE1C mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PDE1C mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PDE1C mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDE1C gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDE1C mRNA16483693
C006780bisphenol Abisphenol A results in increased expression of PDE1C mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of PDE1C mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PDE1C mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PDE1C mRNA26079696
D002104CadmiumCadmium results in decreased expression of PDE1C mRNA24376830
D004390ChlorpyrifosChlorpyrifos affects the expression of PDE1C mRNA17452286
D003471CuprizoneCuprizone results in decreased expression of PDE1C mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of PDE1C mRNA20106945
D003976DiazinonDiazinon affects the expression of PDE1C mRNA17452286
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PDE1C mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PDE1C mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PDE1C mRNA25016146
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PDE1C mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of PDE1C mRNA26924002
D017328FosinoprilFosinopril affects the expression of PDE1C mRNA18209565
D017328FosinoprilFosinopril affects the expression of PDE1C protein18209565
C004312glycidolglycidol results in decreased expression of PDE1C mRNA24915197
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PDE1C mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDE1C mRNA24796395
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PDE1C mRNA12057914
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDE1C mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDE1C mRNA"26251327
D009532NickelNickel results in decreased expression of PDE1C mRNA25583101
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of PDE1C mRNA19074003
C558013NSC 689534NSC 689534 results in increased expression of PDE1C mRNA20971185
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDE1C mRNA"25510870
C551178PF-04254644PF-04254644 results in decreased activity of PDE1C protein20231546
D011374ProgesteroneProgesterone results in decreased expression of PDE1C mRNA21795739
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDE1C mRNA25895662
D012834SilverSilver affects the expression of PDE1C mRNA27131904
D012969Sodium FluorideSodium Fluoride results in increased expression of PDE1C protein28918527
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of PDE1C mRNA26496021
C004648testosterone enanthatetestosterone enanthate results in increased expression of PDE1C mRNA20463352|2142706
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of PDE1C mRNA19074003
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PDE1C mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of PDE1C gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PDE1C mRNA27188386
D014638VanadatesVanadates results in increased expression of PDE1C mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PDE1C gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE1C mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004117calmodulin-dependent cyclic-nucleotide phosphodiesterase activity-TAS-  
GO:0005516calmodulin binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa04020Calcium signaling pathway
hsa04740Olfactory transduction
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111957Cam-PDE 1 activationTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28884473Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. (2017 Sep 8)Schuit ECochrane Database Syst Rev
27344179Associations between smoking behavior-related alleles and the risk of melanoma. (2016 Jul 26)Wu WOncotarget