Gene: ANGPT4

51378
ANG3|ANG4
angiopoietin 4
protein-coding
20p13
Ensembl:ENSG00000101280 MIM:603705 Vega:OTTHUMG00000031652 UniprotKB:Q9Y264
NC_000020.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.382e-2 (AD)  6.818e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4816051chr20:893106 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EEF2K0.376
ALG60.359
NSUN30.353
EFCAB60.35
COL21A10.349
PYROXD10.348
ERI20.342
TSPAN180.339
PRDM50.338
XPO40.337

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MFSD6L-0.261
SERPINC1-0.229
ATP6V0A4-0.224
ANP32C-0.219
RNF223-0.218
SLC22A16-0.218
RGPD6-0.206
C7orf69-0.205
CDH16-0.2
BNIPL-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ANGPT4 mRNA19933214
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of ANGPT4 mRNA25088246
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ANGPT4 gene27153756
D001280AtrazineAtrazine results in increased expression of ANGPT4 mRNA18585445
D004958Estradiol[letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT4 mRNA19620711
D003471CuprizoneCuprizone results in increased expression of ANGPT4 mRNA27523638
D003976DiazinonDiazinon results in increased methylation of ANGPT4 gene22964155
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of ANGPT4 mRNA"27840820
D004237DiuronDiuron results in decreased expression of ANGPT4 mRNA25152437
D004967EstrogensEstrogens results in increased expression of ANGPT4 mRNA22821867
D004967Estrogens[Progesterone co-treated with Estrogens] results in increased expression of ANGPT4 mRNA22821867
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ANGPT4 mRNA23550701
D017313FenretinideFenretinide results in increased expression of ANGPT4 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANGPT4 mRNA25613284
C067431letrozole[letrozole results in decreased abundance of Estradiol] which results in decreased expression of ANGPT4 mRNA19620711
D009538NicotineNicotine results in increased expression of ANGPT4 mRNA23825647
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ANGPT4 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ANGPT4 mRNA25729387
D010100OxygenOxygen results in decreased expression of ANGPT4 mRNA23034257
D011374ProgesteroneProgesterone results in decreased expression of ANGPT4 mRNA23012394
D011374Progesterone[Progesterone co-treated with Estrogens] results in increased expression of ANGPT4 mRNA22821867
D011374ProgesteroneProgesterone results in increased expression of ANGPT4 mRNA22821867
D012834SilverSilver results in increased expression of ANGPT4 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of ANGPT4 mRNA17682005
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANGPT4 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANGPT4 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ANGPT4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ANGPT4 mRNA25729387
D019287Zinc SulfateZinc Sulfate results in increased expression of ANGPT4 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030297transmembrane receptor protein tyrosine kinase activator activity-IDA10051567  15851516  
GO:0030971receptor tyrosine kinase binding-IDA10051567  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001935endothelial cell proliferationNOTIDA10025962  
GO:0007171activation of transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0007219Notch signaling pathway-IEA-  
GO:0010595positive regulation of endothelial cell migration-IDA12958144  
GO:0016525negative regulation of angiogenesis-IDA16790085  
GO:0043066negative regulation of apoptotic process-IDA12958144  15284220  
GO:0043536positive regulation of blood vessel endothelial cell migration-IDA15284220  
GO:0043537negative regulation of blood vessel endothelial cell migration-IDA16790085  
GO:0045766positive regulation of angiogenesis-IDA15284220  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA15851516  
GO:0050900leukocyte migration-TAS-  
GO:0071456cellular response to hypoxia-IEP12958144  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA10025962  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-210993Tie2 SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal