Gene: SCLY

51540
SCL|hSCL
selenocysteine lyase
protein-coding
2q37.3
Ensembl:ENSG00000132330 MIM:611056 Vega:OTTHUMG00000133336 UniprotKB:Q96I15
NC_000002.12
SNP Mapped
31   ANCO-SNPs
AD
0   
7.379e-1 (AD)  2.577e-1 (ND)   (Frontal_Cortex)
6.794e-1 (AD)  6.821e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13006807chr2:238099901 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs41264151chr2:238098994 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs62196004chr2:238097673 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs13033964chr2:238096945 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7591078chr2:238096373 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs34049050chr2:238089940 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2592583chr2:238087119 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2248623chr2:238086187 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2326009chr2:238085216 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2248824chr2:238084463 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2248825chr2:238084404 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2278742chr2:238083155 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2249067chr2:238082546 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2249077chr2:238082344 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4663836chr2:238078544 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2262426chr2:238075856 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2262425chr2:238075488 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2252822chr2:238074626 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7601010chr2:238074132 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2264166chr2:238072660 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2592585chr2:238070980 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2249543chr2:238066170 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs821480chr2:238064186 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs821482chr2:238062470 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2250038chr2:238062302 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2250039chr2:238062296 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2250045chr2:238062221 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2243545chr2:238060509 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1374479chr2:238059384 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs821484chr2:238059011 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs843975chr2:238058924 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FN3K0.871
ARHGEF180.86
YIF1B0.855
SH2B10.85
CDIPT0.845
WRAP730.845
SMG90.844
DEF80.843
SCAMP30.841
ARMC50.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.6
OR4F29-0.553
IL18RAP-0.428
TFPI2-0.386
CEACAM3-0.383
CEACAM4-0.379
HBD-0.376
GSDMA-0.374
KLRF1-0.372
VNN2-0.37

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB11135SeleniumSmall Molecule7782-49-2Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of SCLY mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SCLY mRNA"19114083
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SCLY mRNA"21346803
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to SCLY protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SCLY protein]26598702
D000082AcetaminophenAcetaminophen results in decreased expression of SCLY mRNA21420995
D020106AcrylamideAcrylamide affects the expression of SCLY mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SCLY mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SCLY protein]26598702
C006780bisphenol Abisphenol A affects the expression of SCLY mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of SCLY mRNA26982218
D002065BuspironeBuspirone results in decreased expression of SCLY mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SCLY mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SCLY mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCLY mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SCLY mRNA19320972
D003300CopperCopper results in decreased expression of SCLY mRNA22465980
D016572CyclosporineCyclosporine results in decreased expression of SCLY mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of SCLY mRNA20106945
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of SCLY mRNA]21095227
D003703DemecolcineDemecolcine results in decreased expression of SCLY mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SCLY mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SCLY mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SCLY mRNA27392435
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SCLY protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SCLY mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SCLY mRNA23649840
D011345FenofibrateFenofibrate affects the expression of SCLY mRNA20801182
D005485FlutamideFlutamide results in increased expression of SCLY mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCLY mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SCLY mRNA23649840
C029424hydrazinehydrazine results in increased expression of SCLY mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SCLY mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SCLY mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SCLY mRNA25613284
C410337K 7174K 7174 results in decreased expression of SCLY mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCLY mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SCLY mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SCLY mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of SCLY promoter"26251327
D009151Mustard GasMustard Gas results in increased expression of SCLY mRNA15674844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SCLY mRNA"29244179
C022838nickel chloridenickel chloride affects the expression of SCLY mRNA22110744
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of SCLY protein19716841
D010634PhenobarbitalPhenobarbital results in increased expression of SCLY mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in increased expression of SCLY mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of SCLY mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SCLY mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SCLY mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SCLY mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of SCLY mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCLY mRNA24780913
C080703SK&F 83959SK&F 83959 results in decreased expression of SCLY protein25852303
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of SCLY mRNA]21095227
C009277sodium arsenatesodium arsenate affects the methylation of SCLY promoter20667999
C009277sodium arsenatesodium arsenate results in decreased expression of SCLY mRNA20667999
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCLY mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCLY mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCLY mRNA21724226
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SCLY mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of SCLY mRNA23557971
D014212TretinoinTretinoin results in decreased expression of SCLY mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SCLY mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of SCLY protein21315101
D014635Valproic AcidValproic Acid affects the expression of SCLY mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SCLY mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of SCLY gene29154799
D014635Valproic AcidValproic Acid affects the expression of SCLY mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SCLY gene25560391
D014750VincristineVincristine results in decreased expression of SCLY mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21044950  
GO:0009000selenocysteine lyase activity-TAS-  
GO:0016740transferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001887selenium compound metabolic process-TAS-  
GO:0006520cellular amino acid metabolic process-TAS10692412  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00450Selenocompound metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-2408508Metabolism of ingested SeMet, Sec, MeSec into H2SeTAS
R-HSA-2408522Selenoamino acid metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal