Gene: RAB6B

51560
-
RAB6B, member RAS oncogene family
protein-coding
3q22.1
Ensembl:ENSG00000154917 MIM:615852 Vega:OTTHUMG00000159749 UniprotKB:Q9NRW1
NC_000003.12
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.806e-1 (AD)  6.608e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1880663chr3:133862615 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs17310798chr3:133844095 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2692672chr3:133836656 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6793673chr3:133834428 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11921187chr3:133832798 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2293374chr3:133828401 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12637730chr3:133827453 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00448875chr3:133611626RAB6BGene body3.952e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF3C0.975
CDK5R10.974
ARHGEF90.973
RTN10.973
SULT4A10.972
PPP3CB0.971
SNAP910.971
STXBP10.971
MAPK100.971
SYNGR10.97

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
OR4F29-0.53
TFPI2-0.517
REST-0.491
RAI14-0.488
CSAG1-0.481
WWTR1-0.474
HEY2-0.467
ARHGEF5-0.466
FZD10-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RAB6B mRNA"19114083
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of RAB6B protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAB6B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAB6B mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RAB6B mRNA26690555
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RAB6B mRNA24449571
D001104ArbutinArbutin results in decreased expression of RAB6B mRNA17103032
D001280AtrazineAtrazine results in increased expression of RAB6B mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAB6B mRNA21569818
C006780bisphenol Abisphenol A results in increased methylation of RAB6B promoter27312807
C006780bisphenol Abisphenol A affects the expression of RAB6B mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RAB6B mRNA25181051
C584509C646 compoundC646 compound results in increased expression of RAB6B mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RAB6B mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RAB6B mRNA21457566
D002220CarbamazepineCarbamazepine affects the expression of RAB6B mRNA25979313
D002922CiguatoxinsCiguatoxins affects the expression of RAB6B mRNA18353800
D003471CuprizoneCuprizone results in decreased expression of RAB6B mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of RAB6B mRNA27989131
C526360dechlorane plusdechlorane plus results in decreased expression of RAB6B protein24463492
D013759DronabinolDronabinol results in increased expression of RAB6B mRNA16616335
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RAB6B mRNA27392435
D002945CisplatinCisplatin results in increased expression of RAB6B mRNA27392435
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of RAB6B mRNA17490981
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RAB6B mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAB6B mRNA]17942915
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of RAB6B mRNA"22485181
D004147DioxinsDioxins affects the expression of RAB6B mRNA20463971
C039281furanfuran results in increased expression of RAB6B mRNA27387713
D017313FenretinideFenretinide results in increased expression of RAB6B mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RAB6B mRNA20044591
C492448ICG 001ICG 001 results in increased expression of RAB6B mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RAB6B mRNA27392435
C011890kojic acidkojic acid results in decreased expression of RAB6B mRNA16595896
D007854LeadLead affects the expression of RAB6B mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RAB6B mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RAB6B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RAB6B mRNA"25554681
D009532NickelNickel results in decreased expression of RAB6B mRNA24768652|2558310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAB6B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of RAB6B mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of RAB6B protein23718831
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAB6B mRNA25895662
C016104sodium bichromatesodium bichromate results in increased expression of RAB6B mRNA22561333
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAB6B mRNA21570461
C009495titanium dioxidetitanium dioxide results in decreased expression of RAB6B mRNA23557971|2776080
D024505TocopherolsTocopherols results in increased expression of RAB6B mRNA17654050
C011559tributyltintributyltin results in decreased expression of RAB6B mRNA27614199
C012589trichostatin Atrichostatin A results in decreased expression of RAB6B mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of RAB6B mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RAB6B mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of RAB6B mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of RAB6B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RAB6B mRNA19101580|2317975
C029297vinylidene chloridevinylidene chloride results in decreased expression of RAB6B mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-NAS10893188  
GO:0005515protein binding-IPI23737971  27107012  
GO:0005525GTP binding-IEA-  
GO:0031489myosin V binding-IPI24006491  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-IBA21873635  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-NAS10893188  
GO:0006891intra-Golgi vesicle-mediated transport-IBA21873635  
GO:0015031protein transport-IEA-  
GO:0032482Rab protein signal transduction-IBA21873635  
GO:0042147retrograde transport, endosome to Golgi-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IEA-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA-  
GO:0005794Golgi apparatus-NAS10893188  
GO:0005829cytosol-IEA-  
GO:0012505endomembrane system-IBA21873635  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6811436COPI-independent Golgi-to-ER retrograde trafficTAS
R-HSA-6811440Retrograde transport at the Trans-Golgi-NetworkTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-8873719RAB geranylgeranylationTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal