Gene: PDGFRL

5157
PDGRL|PRLTS
platelet derived growth factor receptor like
protein-coding
8p22
Ensembl:ENSG00000104213 MIM:604584 Vega:OTTHUMG00000130818 UniprotKB:Q15198
NG_023332.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.156e-1 (AD)  6.141e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2588112chr8:17618805 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIST1H2AC0.608
TRIP40.597
MTA20.586
ZNF830.582
CALCOCO20.58
OFD10.58
PPIL40.577
CLN50.576
HEBP10.576
IRF20.571

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.288
CYP1A1-0.278
OR4F5-0.26
ABCC12-0.248
OSTN-0.241
CHST13-0.24
VIP-0.239
ADRA1D-0.238
RHO-0.237
OR4F29-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of PDGFRL mRNA19041380
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PDGFRL mRNA"25614096
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDGFRL mRNA"28973690
D000082AcetaminophenAcetaminophen affects the expression of PDGFRL mRNA17562736
D000393Air PollutantsAir Pollutants analog results in decreased expression of PDGFRL mRNA21757418
D000638AmiodaroneAmiodarone results in increased expression of PDGFRL mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PDGFRL mRNA24449571
C547126AZM551248AZM551248 results in increased expression of PDGFRL mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of PDGFRL mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of PDGFRL mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDGFRL mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDGFRL mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of PDGFRL mRNA21185374
D004958EstradiolEstradiol results in decreased expression of PDGFRL mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of PDGFRL mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PDGFRL mRNA24763279
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PDGFRL mRNA21356183
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDGFRL mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDGFRL mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PDGFRL mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PDGFRL mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of PDGFRL mRNA20106945
C014347decitabinedecitabine results in increased expression of PDGFRL mRNA15251184
C014347decitabine[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PDGFRL mRNA15251184
D003907DexamethasoneDexamethasone results in decreased expression of PDGFRL mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDGFRL mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PDGFRL mRNA21266533
D004026DieldrinDieldrin results in decreased expression of PDGFRL mRNA28385952
D004041Dietary FatsDietary Fats results in increased expression of PDGFRL mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PDGFRL mRNA17005392
D002117CalcitriolCalcitriol results in decreased expression of PDGFRL mRNA26485663
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of PDGFRL mRNA28939011
D004147DioxinsDioxins affects the expression of PDGFRL mRNA20463971
D004237DiuronDiuron results in increased expression of PDGFRL mRNA21551480
C118739entinostatentinostat results in increased expression of PDGFRL mRNA27188386
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of PDGFRL mRNA20846436
C039281furanfuran results in increased expression of PDGFRL mRNA25539665|2738771
D005839GentamicinsGentamicins results in decreased expression of PDGFRL mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PDGFRL mRNA24763279
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDGFRL mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDGFRL mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PDGFRL mRNA28628672
C544151jinfukangjinfukang results in increased expression of PDGFRL mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFRL mRNA26644586
C410337K 7174K 7174 results in decreased expression of PDGFRL mRNA24086573
D018021Lithium ChlorideLithium Chloride results in increased expression of PDGFRL mRNA23527032
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDGFRL mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PDGFRL mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PDGFRL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of PDGFRL mRNA"25554681
C022838nickel chloridenickel chloride results in decreased expression of PDGFRL mRNA24612858
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PDGFRL mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PDGFRL mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of PDGFRL mRNA26516004
D000073878Palm OilPalm Oil results in increased expression of PDGFRL mRNA18042831
C006253pirinixic acidpirinixic acid results in increased expression of PDGFRL mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of PDGFRL mRNA23557933
D011794QuercetinQuercetin results in decreased expression of PDGFRL mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of PDGFRL mRNA21632981
D012834SilverSilver results in decreased expression of PDGFRL mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of PDGFRL gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of PDGFRL mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of PDGFRL mRNA24612858
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PDGFRL mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDGFRL mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PDGFRL mRNA15251184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDGFRL mRNA15251184
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDGFRL mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of PDGFRL mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDGFRL mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PDGFRL mRNA25729387
D019772TopotecanTopotecan results in increased expression of PDGFRL mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PDGFRL mRNA20530235
D014212TretinoinTretinoin results in decreased expression of PDGFRL mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PDGFRL mRNA"26179874
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of PDGFRL mRNA28666766
D014520UrethaneUrethane results in decreased expression of PDGFRL mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PDGFRL mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PDGFRL mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of PDGFRL mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of PDGFRL mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PDGFRL gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of PDGFRL mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004992platelet activating factor receptor activity-TAS7898930  
GO:0005019platelet-derived growth factor beta-receptor activity-TAS7898930  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0008150biological_process-ND-  
GO:0035791platelet-derived growth factor receptor-beta signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal