Gene: LARP7

51574
ALAZS|HDCMA18P|PIP7S
La ribonucleoprotein domain family member 7
protein-coding
4q25
Ensembl:ENSG00000174720 MIM:612026 Vega:OTTHUMG00000132909 UniprotKB:Q4G0J3
NG_032779.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.477e-1 (AD)  7.455e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13146963chr4:112637446 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMC20.852
TMBIM40.839
MRPS140.821
ATRAID0.819
DAZAP20.818
SYF20.817
LSM14A0.816
RHOA0.812
GINM10.811
FNTA0.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.667
OR4F5-0.659
EPPIN-0.275
OPRD1-0.243
ADRA1D-0.233
PROZ-0.208
HCN4-0.206
CILP2-0.199
COL22A1-0.19
NHLH1-0.186

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LARP7 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LARP7 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LARP7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LARP7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LARP7 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LARP7 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of LARP7 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LARP7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LARP7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LARP7 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of LARP7 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of LARP7 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LARP7 mRNA]17585979
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of LARP7 protein26072098
C006780bisphenol Abisphenol A affects the expression of LARP7 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LARP7 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of LARP7 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LARP7 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of LARP7 mRNA25979313
D000068579CelecoxibCelecoxib results in increased expression of LARP7 mRNA28201806
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LARP7 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LARP7 mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of LARP7 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LARP7 mRNA]17585979
C014347decitabinedecitabine results in increased expression of LARP7 mRNA19194470
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of LARP7 protein23352502
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LARP7 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LARP7 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of LARP7 mRNA28302478
D004317DoxorubicinDoxorubicin results in increased oxidation of LARP7 protein28818578
C118739entinostatentinostat results in increased expression of LARP7 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LARP7 mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of LARP7 mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LARP7 protein23301498
D000431EthanolEthanol results in decreased expression of LARP7 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LARP7 mRNA17555576
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of LARP7 mRNA22634610
D017313FenretinideFenretinide results in increased expression of LARP7 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LARP7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LARP7 mRNA28628672
C011890kojic acidkojic acid results in decreased expression of LARP7 mRNA16595896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LARP7 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LARP7 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LARP7 mRNA"20188158
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of LARP7 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of LARP7 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of LARP7 mRNA27153767
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LARP7 mRNA22714537
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased expression of LARP7 mRNA19194470
D012402RotenoneRotenone results in decreased expression of LARP7 mRNA27900601
D012999SomanSoman results in decreased expression of LARP7 mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of LARP7 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of LARP7 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LARP7 mRNA19465110
D013849ThimerosalThimerosal results in increased expression of LARP7 mRNA27188386
D014212TretinoinTretinoin results in decreased expression of LARP7 mRNA21934132
C012589trichostatin Atrichostatin A affects the expression of LARP7 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of LARP7 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of LARP7 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of LARP7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LARP7 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of LARP7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LARP7 mRNA24935251|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LARP7 gene25560391
C111237vorinostatvorinostat results in increased expression of LARP7 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI18281698  18483487  20562857  23455922  23602568  25470060  
26659056  
GO ID GO Term Qualifier Evidence PubMed
GO:0006396RNA processing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:1990904ribonucleoprotein complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal