Gene: ZFR

51663
SPG71|ZFR1
zinc finger RNA binding protein
protein-coding
5p13.3
Ensembl:ENSG00000056097 MIM:615635 Vega:OTTHUMG00000161979 UniprotKB:Q96KR1
NG_051591.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.906e-1 (AD)  6.122e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs641221chr5:32439218 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXW110.906
WAC0.902
CSDE10.896
RAD210.893
UBL30.891
EIF4G20.891
ZMYND110.887
SERINC10.886
EGLN10.885
YWHAQ0.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.777
OR4F5-0.756
C8orf74-0.185
KLRB1-0.172
CSAG1-0.168
C16orf97-0.167
XCL2-0.166
NCR1-0.165
C17orf112-0.162
MTRNR2L3-0.162

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of ZFR mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ZFR mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFR mRNA"27188386
C025154alpha-cobratoxinalpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]12588870
D001151ArsenicArsenic affects the methylation of ZFR gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZFR mRNA21715664
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZFR mRNA"19150397|2623829
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of ZFR protein]25150618
C044887beta-methylcholinebeta-methylcholine affects the expression of ZFR mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ZFR mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ZFR mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ZFR mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ZFR mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFR mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ZFR mRNA26472689
C054133casticincasticin results in decreased expression of ZFR mRNA28444820
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of ZFR protein]25150618
D003300CopperCopper deficiency affects the expression of ZFR protein25150618
D019327Copper SulfateCopper Sulfate results in decreased expression of ZFR mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of ZFR mRNA19789285
D003520CyclophosphamideCyclophosphamide results in decreased expression of ZFR mRNA27281708
D016572CyclosporineCyclosporine results in increased expression of ZFR mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFR mRNA28628672
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of ZFR mRNA23625948
D004041Dietary FatsDietary Fats results in decreased expression of ZFR mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of ZFR mRNA25016146
D004147DioxinsDioxins affects the expression of ZFR mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ZFR protein23301498
D005485FlutamideFlutamide results in increased expression of ZFR mRNA24136188
D004397FonofosFonofos results in decreased methylation of ZFR promoter22847954
C001277geldanamycingeldanamycin results in increased expression of ZFR mRNA26705709
D005839GentamicinsGentamicins results in increased expression of ZFR mRNA22061828
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ZFR mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFR mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZFR mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZFR mRNA28628672
C544151jinfukangjinfukang results in decreased expression of ZFR mRNA27392435
C410337K 7174K 7174 results in increased expression of ZFR mRNA24086573
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ZFR mRNA26378955
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ZFR mRNA26378955
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]12588870
D008464MecamylamineMecamylamine results in decreased expression of ZFR mRNA12588870
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ZFR mRNA23179753|2627250
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZFR mRNA26011545
D009538Nicotinealpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]12588870
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]12588870
D009538NicotineNicotine results in decreased expression of ZFR mRNA12588870
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]12588870
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ZFR mRNA19074003
D000073878Palm OilPalm Oil results in decreased expression of ZFR mRNA18042831
D010278ParathionParathion results in decreased methylation of ZFR promoter22847954
D010634PhenobarbitalPhenobarbital affects the expression of ZFR mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ZFR mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ZFR mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of ZFR mRNA18037150
C059514resveratrolresveratrol results in decreased expression of ZFR protein25505154
C009277sodium arsenatesodium arsenate results in increased expression of ZFR mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of ZFR mRNA28595984
D012969Sodium FluorideSodium Fluoride results in decreased expression of ZFR protein28918527
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ZFR mRNA26378955
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ZFR mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of ZFR mRNA"26680231
C012568terbufosterbufos results in decreased methylation of ZFR promoter22847954
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ZFR mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZFR mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZFR mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of ZFR protein24648495
D013853ThioacetamideThioacetamide results in increased expression of ZFR mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ZFR mRNA22363418
C483909torcetrapibtorcetrapib results in increased expression of ZFR mRNA23228038
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFR mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of ZFR mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of ZFR mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZFR mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of ZFR mRNA28973697
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]12588870
D014403TubocurarineTubocurarine results in decreased expression of ZFR mRNA12588870
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ZFR mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of ZFR mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ZFR gene25560391
C111237vorinostatvorinostat results in decreased expression of ZFR mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003727single-stranded RNA binding-IBA21873635  
GO:0005515protein binding-IPI20195357  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005694chromosome-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal