Gene: SLC26A4

5172
DFNB4|EVA|PDS|TDH2B
solute carrier family 26 member 4
protein-coding
7q22.3
Ensembl:ENSG00000091137 MIM:605646 Vega:OTTHUMG00000154807 UniprotKB:O43511
NG_008489.1
SNP Mapped
8   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.206e-1 (AD)  3.472e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2712218chr7:107716314 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2712207chr7:107711672 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2712208chr7:107703317 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs982915chr7:107699466 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2188561chr7:107695613 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2237679chr7:107693581 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1858930chr7:107688092 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2712210chr7:107687407 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKAA20.887
ICA1L0.886
SOWAHB0.878
ZNF3820.877
RASAL20.875
DGKE0.874
ZNF385B0.872
PHTF10.871
GRIK20.871
DOPEY10.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.559
MDFI-0.526
EMP3-0.499
ROM1-0.489
BCL7C-0.484
HEY2-0.479
CNN2-0.469
WWTR1-0.467
CMTM3-0.466
MYL3-0.465

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of SLC26A4 mRNA"26377693
C0942102,2'-(hydroxynitrosohydrazono)bis-ethanamine"2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in decreased expression of SLC26A4 protein"22811483
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one results in increased expression of SLC26A4 protein"22811483
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SLC26A4 mRNA25088246
D000082AcetaminophenAcetaminophen results in decreased expression of SLC26A4 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of SLC26A4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SLC26A4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC26A4 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of SLC26A4 mRNA"21730038
D000584Amiloride[Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein17311909
D000638AmiodaroneAmiodarone results in decreased expression of SLC26A4 mRNA18020914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC26A4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLC26A4 mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC26A4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC26A4 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC26A4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC26A4 mRNA25908611
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC26A4 mRNA21839799
C006780bisphenol Abisphenol A results in increased expression of SLC26A4 mRNA27183338
C006780bisphenol Abisphenol A results in decreased expression of SLC26A4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC26A4 mRNA27257137
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC26A4 protein22811483
C018475butyraldehydebutyraldehyde results in decreased expression of SLC26A4 mRNA26079696
D002712ChloridesSLC26A4 protein affects the transport of Chlorides22116359
D002712ChloridesSLC26A4 protein mutant form affects the transport of Chlorides22116360
D002712ChloridesSLC26A4 protein results in increased transport of Chlorides22116360
D002737ChloropreneChloroprene results in decreased expression of SLC26A4 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC26A4 mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of SLC26A4 mRNA18353800
D003042CocaineCocaine affects the expression of SLC26A4 mRNA20187946
D005576ColforsinColforsin results in increased expression of SLC26A4 protein22811483
D003300CopperCopper results in decreased expression of SLC26A4 mRNA22465980
D003471CuprizoneCuprizone results in decreased expression of SLC26A4 mRNA26577399
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of SLC26A4 mRNA"25908611
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of SLC26A4 mRNA26924002
D004026DieldrinDieldrin results in increased expression of SLC26A4 mRNA23041725
C024629dimethyl phthalatedimethyl phthalate results in increased expression of SLC26A4 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC26A4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC26A4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC26A4 mRNA15834898|1755790
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC26A4 mRNA23550701
C030544formic acidSLC26A4 protein results in increased transport of formic acid10644529
C069837fullerene C60fullerene C60 results in increased expression of SLC26A4 mRNA20471445
D005665FurosemideFurosemide affects the localization of SLC26A4 protein17311909
D005665Furosemide[Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein17311909
D005839GentamicinsGentamicins results in decreased expression of SLC26A4 mRNA22061828
D007454IodidesSLC26A4 protein affects the transport of Iodides22116359
D007455IodineIodine results in increased expression of SLC26A4 mRNA15922087
D007455IodineMethylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA]15922087
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC26A4 mRNA23103053
D008770MethylnitrosoureaMethylnitrosourea promotes the reaction [Iodine results in increased expression of SLC26A4 mRNA]15922087
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of SLC26A4 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC26A4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC26A4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC26A4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC26A4 mRNA"25554681|2710602
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC26A4 mRNA"19836432|2491129
D009532NickelNickel results in increased expression of SLC26A4 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of SLC26A4 mRNA19167457
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in increased expression of SLC26A4 mRNA"16823509
D043371Fatty Acids, Omega-6"Fatty Acids, Omega-6 results in decreased expression of SLC26A4 mRNA"16823509
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of SLC26A4 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of SLC26A4 mRNA25658374
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of SLC26A4 mRNA]19555225
D052638Particulate MatterParticulate Matter results in decreased expression of SLC26A4 mRNA28655636
D010634PhenobarbitalPhenobarbital affects the expression of SLC26A4 mRNA19084549
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC26A4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SLC26A4 mRNA19482888
D059808PolyphenolsPolyphenols results in decreased expression of SLC26A4 mRNA16293270
C019536potassium bromatepotassium bromate results in decreased expression of SLC26A4 mRNA23588252
D011374ProgesteroneProgesterone results in decreased expression of SLC26A4 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC26A4 mRNA24780913
D011791QuartzQuartz results in increased expression of SLC26A4 mRNA19836432
D012293RifampinRifampin results in decreased expression of SLC26A4 mRNA27199754
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLC26A4 mRNA26345256
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLC26A4 mRNA22431001
D012969Sodium FluorideSodium Fluoride results in increased expression of SLC26A4 mRNA27257137
D053260SootSoot results in increased expression of SLC26A4 mRNA22461453|2655175
D013739TestosteroneTestosterone results in increased expression of SLC26A4 mRNA27684650
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC26A4 mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of SLC26A4 mRNA19464567|2125934
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SLC26A4 mRNA20133372
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SLC26A4 mRNA19042947
D014640VancomycinVancomycin results in increased expression of SLC26A4 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of SLC26A4 mRNA28655636
C025643vinclozolinvinclozolin results in increased expression of SLC26A4 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC26A4 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005254chloride channel activity-IBA21873635  
GO:0008271secondary active sulfate transmembrane transporter activity-IEA-  
GO:0015106bicarbonate transmembrane transporter activity-IBA21873635  
GO:0015108chloride transmembrane transporter activity-TAS10192399  
GO:0015111iodide transmembrane transporter activity-TAS-  
GO:0015116sulfate transmembrane transporter activity-IBA21873635  
GO:0015116sulfate transmembrane transporter activity-TAS9398842  
GO:0015301anion:anion antiporter activity-IBA21873635  
GO:0019531oxalate transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0006885regulation of pH-ISS-  
GO:0007605sensory perception of sound-TAS9398842  10192399  
GO:0008272sulfate transport-TAS9398842  
GO:0015698inorganic anion transport-TAS10192399  
GO:0015701bicarbonate transport-IBA21873635  
GO:0015705iodide transport-IEA-  
GO:0019532oxalate transport-IBA21873635  
GO:0019532oxalate transport-IEA-  
GO:0032880regulation of protein localization-ISS-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:1902358sulfate transmembrane transport-IBA21873635  
GO:1902358sulfate transmembrane transport-IEA-  
GO:1902476chloride transmembrane transport-IBA21873635  
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-TAS10192399  
GO:0016324apical plasma membrane-IDA16928804  
GO:0016324apical plasma membrane-ISS-  
GO:0031526brush border membrane-ISS-  
GO:0070062extracellular exosome-HDA19056867  
GO:0070062extracellular exosome-IDA21082674  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-427601Multifunctional anion exchangersTAS
R-HSA-5619046Defective SLC26A4 causes Pendred syndrome (PDS)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal