Gene: WWOX

51741
D16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
WW domain containing oxidoreductase
protein-coding
16q23.1-q23.2
Ensembl:ENSG00000186153 MIM:605131 Vega:OTTHUMG00000176851 UniprotKB:Q9NZC7
NG_011698.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
3   
1.447e-1 (AD)  3.969e-1 (ND)   (Frontal_Cortex)
4.672e-2 (AD)  1.773e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9935088chr16:78945618 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs17640190chr16:78560010 (GRCh38.p7)G>A / G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2738652chr16:78460459 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4508428chr16:78269369 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26700469chr16:79155427WWOXGene body3.370e-4Alcohol use disorders26763658
cg10001715chr16:78345421WWOX2.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HTRA10.83
CSRP10.816
ALDH9A10.809
GPR137B0.808
PGM10.802
GLUD10.801
BBS20.801
CRYL10.8
ALDH20.799
GPM6B0.798

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.553
OR4F29-0.517
FER1L6-0.301
LOXHD1-0.297
HRH2-0.295
KLHL38-0.294
FCER2-0.279
SLC12A3-0.277
IGSF9B-0.277
FAM160A1-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of WWOX protein"27026707
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl affects the expression of WWOX mRNA"24050789
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of WWOX mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of WWOX mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of WWOX mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of WWOX mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of WWOX mRNA"25510870
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of WWOX mRNA15618236
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of WWOX protein15618236
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWOX mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWOX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWOX mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWOX mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of WWOX mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of WWOX mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of WWOX protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of WWOX mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WWOX mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 affects the expression of WWOX mRNA22545673
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of WWOX mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of WWOX mRNA21298039
D001151ArsenicArsenic affects the methylation of WWOX gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of WWOX mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WWOX mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WWOX mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WWOX mRNA19770486|2071347
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WWOX mRNA"26238291
D004958EstradiolEstradiol results in decreased phosphorylation of WWOX protein27026707
C006780bisphenol Abisphenol A results in decreased expression of WWOX mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of WWOX gene22576693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WWOX mRNA28628672
C006780bisphenol Abisphenol A affects the expression of WWOX mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of WWOX gene28505145
D002220CarbamazepineCarbamazepine affects the expression of WWOX mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of WWOX mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of WWOX mRNA20938992
D009249NADPNADP binds to and results in increased activity of WWOX protein25526675
D019327Copper SulfateCopper Sulfate results in decreased expression of WWOX mRNA19549813
D003513CycloheximideWWOX gene SNP affects the susceptibility to Cycloheximide25622337
D016572CyclosporineCyclosporine results in decreased expression of WWOX mRNA19770486
C014347decitabinedecitabine affects the expression of WWOX protein17200365
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of WWOX protein17019711
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in decreased expression of WWOX protein]23618899
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WWOX mRNA28628672
D003976DiazinonDiazinon affects the expression of WWOX mRNA22546817
D002945CisplatinCisplatin results in decreased expression of WWOX mRNA21151649
D004026DieldrinDieldrin affects the expression of WWOX mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of WWOX mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of WWOX mRNA21607683
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of WWOX mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of WWOX mRNA]17942915
C118739entinostatentinostat results in increased expression of WWOX mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWOX mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of WWOX mRNA23649840
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of WWOX mRNA21607683
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of WWOX mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of WWOX mRNA23649840|2766457
C071834glycidamideglycidamide results in decreased expression of WWOX mRNA17822822
D017313FenretinideFenretinide results in decreased expression of WWOX mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of WWOX mRNA20044591
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of WWOX protein18951874
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WWOX protein18951874
C016517indole-3-carbinolindole-3-carbinol affects the expression of WWOX mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WWOX mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of WWOX mRNA28628672
C544151jinfukangjinfukang results in increased expression of WWOX mRNA27392435
D048628KetolidesKetolides analog results in increased expression of WWOX mRNA24967691
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of WWOX mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of WWOX mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of WWOX mRNA20713471
C005223methyleugenolmethyleugenol results in decreased expression of WWOX protein15618236
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of WWOX mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WWOX mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WWOX mRNA23649840
C410127PCB 180PCB 180 affects the expression of WWOX mRNA24050789
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of WWOX mRNA"25510870
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of WWOX mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of WWOX mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of WWOX mRNA19482888
C012526quercitrinquercitrin results in decreased expression of WWOX mRNA25193878
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of WWOX mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of WWOX mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of WWOX mRNA25351596
D012906SmokeSmoke results in decreased expression of WWOX mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of WWOX mRNA23922661
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in decreased expression of WWOX protein]23618899
C017947sodium arsenitesodium arsenite affects the expression of WWOX mRNA29319823
C017947sodium arsenitesodium arsenite affects the methylation of WWOX gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of WWOX mRNA23618899
C017947sodium arsenitesodium arsenite results in decreased expression of WWOX protein23618899
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in decreased expression of WWOX protein]23618899
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of WWOX mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WWOX mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WWOX mRNA19770486
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of WWOX protein18951874
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of WWOX protein18951874
D013853ThioacetamideThioacetamide results in decreased expression of WWOX mRNA23411599
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of WWOX protein17019711
C057693troglitazonetroglitazone results in decreased expression of WWOX mRNA28973697
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in decreased expression of WWOX protein]23618899
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWOX mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of WWOX mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WWOX mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of WWOX mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of WWOX gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of WWOX mRNA20044591
C111237vorinostatvorinostat results in increased expression of WWOX mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activitycontributes_toISS19366691  
GO:0005515protein binding-IPI15064722  15070730  15580310  16061658  19465938  25678599  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0016491oxidoreductase activity-NAS10861292  
GO:0016491oxidoreductase activity-TAS10786676  
GO:0019899enzyme binding-IPI19366691  
GO:0046983protein dimerization activity-TAS10786676  
GO:0048037cofactor binding-TAS10786676  
GO:0050662coenzyme binding-TAS10786676  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS-  
GO:0001649osteoblast differentiation-IEA-  
GO:0008202steroid metabolic process-TAS10786676  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-IDA19465938  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048705skeletal system morphogenesis-ISS-  
GO:0055114oxidation-reduction process-TAS10786676  
GO:0071560cellular response to transforming growth factor beta stimulus-IDA19366691  
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator-IEA-  
GO:0097191extrinsic apoptotic signaling pathway-IEA-  
GO:2001238positive regulation of extrinsic apoptotic signaling pathway-ISS-  
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19366691  
GO:0005737cytoplasm-IDA19465938  
GO:0005737cytoplasm-TAS10786676  
GO:0005739mitochondrion-ISS-  
GO:0005794Golgi apparatus-IDA15064722  
GO:0005829cytosol-IDA19366691  
GO:0005829cytosol-TAS-  
GO:0005886plasma membranecolocalizes_withIDA19366691  
GO:0005902microvilluscolocalizes_withIDA19366691  
GO:0090575RNA polymerase II transcription factor complex-ISS19366691  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1251985Nuclear signaling by ERBB4TAS
R-HSA-162582Signal TransductionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsTAS
R-HSA-8866907Activation of the TFAP2 (AP-2) family of transcription factorsTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16116962Deletion and mutation of WWOX exons 6-8 in human non-small cell lung cancer. (2005)Zhou YJ Huazhong Univ Sci Technolog Med Sci
22248280Cigarette smoking extract causes hypermethylation and inactivation of WWOX gene in T-24 human bladder cancer cells. (2012)Yang WNeoplasma
24098343Genome-wide association study of gene by smoking interactions in coronary artery calcification. (2013)Polfus LMPLoS One