Gene: ATP8A2

51761
ATP|ATPIB|CAMRQ4|IB|ML-1
ATPase phospholipid transporting 8A2
protein-coding
13q12.13
Ensembl:ENSG00000132932 MIM:605870 Vega:OTTHUMG00000016611 UniprotKB:Q9NTI2
NG_042855.1
SNP Mapped
6   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.844e-1 (AD)  3.389e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1324408chr13:25942322 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs184249chr13:25935931 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4770875chr13:25745589 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs9634421chr13:25735110 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17685787chr13:25688042 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs13378890chr13:25422552 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00893603chr13:26587011ATP8A24.700e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBEA0.974
STXBP5L0.973
NMNAT20.972
GLT1D10.972
FAXC0.971
FRMPD40.971
DYNC1I10.971
MAP7D20.97
HECW10.968
DCLK10.968

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.613
YES1-0.612
RAB13-0.61
RNF135-0.603
REST-0.597
CHST14-0.589
MYL3-0.585
CSAG1-0.583
COPZ2-0.581
ROM1-0.572

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in increased methylation of ATP8A2 gene"25445006
D000082AcetaminophenAcetaminophen results in decreased expression of ATP8A2 mRNA26690555
D001151ArsenicArsenic affects the methylation of ATP8A2 gene25304211
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ATP8A2 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of ATP8A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ATP8A2 mRNA29097150
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATP8A2 mRNA29097150
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of ATP8A2 mRNA22563483
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ATP8A2 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ATP8A2 mRNA26011545
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of ATP8A2 mRNA22563483
D010269ParaquatParaquat results in increased expression of ATP8A2 mRNA22563483
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ATP8A2 mRNA20660070
C428725pyridabenpyridaben results in increased expression of ATP8A2 mRNA22563483
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ATP8A2 mRNA23806026
D012906SmokeSmoke results in increased expression of ATP8A2 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of ATP8A2 gene28589171
C012589trichostatin Atrichostatin A results in decreased expression of ATP8A2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of ATP8A2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ATP8A2 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ATP8A2 gene25487561
C111237vorinostatvorinostat results in decreased expression of ATP8A2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004012phospholipid-translocating ATPase activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003011involuntary skeletal muscle contraction-IEA-  
GO:0007409axonogenesis-IEA-  
GO:0007568aging-IEA-  
GO:0008285negative regulation of cell proliferation-TAS10551800  
GO:0010842retina layer formation-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0010996response to auditory stimulus-IEA-  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0042472inner ear morphogenesis-IEA-  
GO:0042755eating behavior-IEA-  
GO:0043588skin development-IEA-  
GO:0045332phospholipid translocation-IBA21873635  
GO:0045332phospholipid translocation-IEA-  
GO:0048666neuron development-IBA21873635  
GO:0050884neuromuscular process controlling posture-IEA-  
GO:0050908detection of light stimulus involved in visual perception-IEA-  
GO:0060052neurofilament cytoskeleton organization-IEA-  
GO:0061092positive regulation of phospholipid translocation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005768endosome-IEA-  
GO:0005794Golgi apparatus-IDA20947505  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA20947505  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-936837Ion transport by P-type ATPasesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal