Gene: PEX14

5195
NAPP2|PBD13A|Pex14p|dJ734G22.2
peroxisomal biogenesis factor 14
protein-coding
1p36.22
Ensembl:ENSG00000142655 MIM:601791 Vega:OTTHUMG00000001908 UniprotKB:O75381
NG_008340.1
SNP Mapped
12   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.344e-1 (AD)  8.625e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs284303chr1:10630826 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs185864chr1:10627669 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs190775chr1:10623626 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs284235chr1:10618786 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs284237chr1:10618553 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs284238chr1:10618431 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3790630chr1:10613037 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6666075chr1:10609041 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12722934chr1:10608322 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11121599chr1:10606678 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11121598chr1:10598145 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10864468chr1:10595652 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STOML10.963
ATP13A20.963
P4HTM0.961
FBXO440.958
IRF2BP10.955
MAPRE30.955
SLC22A170.955
OTUB10.954
AP1M10.953
USP200.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.62
OR4F29-0.569
TFPI2-0.501
KCNJ15-0.48
EBF1-0.473
MTRNR2L6-0.466
MTRNR2L9-0.466
IL18RAP-0.46
PABPC4L-0.453
KLRB1-0.448

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of PEX14 mRNA"19114083
D020106AcrylamideAcrylamide results in decreased expression of PEX14 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PEX14 gene28458013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PEX14 mRNA16483693
D001151ArsenicArsenic affects the methylation of PEX14 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PEX14 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PEX14 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of PEX14 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PEX14 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of PEX14 mRNA26191083
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PEX14 mRNA24763279
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEX14 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of PEX14 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PEX14 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PEX14 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of PEX14 mRNA24921660
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PEX14 mRNA17602206
D018120FinasterideFinasteride results in increased expression of PEX14 mRNA24136188
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PEX14 mRNA24763279
C492448ICG 001ICG 001 results in decreased expression of PEX14 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PEX14 mRNA23086925
D008628MercuryMercury results in increased expression of PEX14 mRNA16823088
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PEX14 mRNA19429403|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PEX14 mRNA19429403
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PEX14 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PEX14 mRNA17426115|1830175
D011748PyrogallolPyrogallol results in decreased expression of PEX14 mRNA20362636
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PEX14 mRNA21427059
D012643SeleniumSelenium results in increased expression of PEX14 mRNA19244175
C009250sevofluranesevoflurane affects the expression of PEX14 mRNA15967596
C017947sodium arsenitesodium arsenite results in decreased expression of PEX14 mRNA16507463
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PEX14 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEX14 mRNA21215274
D013853ThioacetamideThioacetamide results in increased expression of PEX14 mRNA16297948
C000602704UF010 compoundUF010 compound results in increased acetylation of PEX14 protein25699604
D014635Valproic AcidValproic Acid affects the expression of PEX14 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PEX14 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PEX14 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of PEX14 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of PEX14 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-IDA11863372  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005102signaling receptor binding-IPI10022913  21525035  21976670  
GO:0005515protein binding-IPI9653144  10562279  10704444  11863372  12096124  19197237  
19584060  21525035  
GO:0008017microtubule binding-IDA21525035  
GO:0042802identical protein binding-IPI12096124  
GO:0047485protein N-terminus binding-IPI11863372  
GO:0048487beta-tubulin binding-IPI21525035  
GO ID GO Term Qualifier Evidence PubMed
GO:0006625protein targeting to peroxisome-TAS-  
GO:0007031peroxisome organizationNOTIGI10022913  
GO:0007031peroxisome organization-ISS-  
GO:0016558protein import into peroxisome matrix-IMP15146459  
GO:0016560protein import into peroxisome matrix, docking-IBA21873635  
GO:0016561protein import into peroxisome matrix, translocation-IDA21525035  
GO:0016567protein ubiquitination-TAS-  
GO:0032091negative regulation of protein binding-IDA21976670  
GO:0034453microtubule anchoring-IDA21525035  
GO:0036250peroxisome transport along microtubule-IDA21525035  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA11863372  
GO:0044721protein import into peroxisome matrix, substrate release-IDA21976670  
GO:0045892negative regulation of transcription, DNA-templated-IDA11863372  
GO:0051260protein homooligomerization-IDA12488033  
GO:0065003protein-containing complex assembly-IDA21525035  
GO:1901094negative regulation of protein homotetramerization-IDA21976670  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005622intracellular-IDA21976670  
GO:0005634nucleus-NAS11863372  
GO:0005777peroxisome-IDA16449325  17881773  19197237  21375735  
GO:0005778peroxisomal membrane-HDA21525035  
GO:0005778peroxisomal membrane-IBA21873635  
GO:0005778peroxisomal membrane-IDA10022913  11669066  16449325  18346465  
GO:0005778peroxisomal membrane-ISS-  
GO:0005778peroxisomal membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-ISS-  
GO:0032991protein-containing complex-IDA19584060  
GO:0032991protein-containing complex-ISS-  
GO:1990429peroxisomal importomer complex-IBA21873635  
KEGG ID KEGG Term
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal