Gene: PIK3C2B

5287
C2-PI3K
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
protein-coding
1q32.1
Ensembl:ENSG00000133056 MIM:602838 Vega:OTTHUMG00000036101 UniprotKB:O00750
NC_000001.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.831e-1 (AD)  6.430e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2137255chr1:204457245 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4951373chr1:204423129 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLCO3A10.853
AMOTL20.845
DIP2A0.837
CNTN20.824
TMEM63A0.823
CYTH10.815
SPTLC20.814
ABCA20.808
TMC70.804
NXPE30.804

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.401
OR4F29-0.394
WNT7B-0.255
PLA2G5-0.233
OR4F16-0.23
PPP1R3G-0.229
TNNT1-0.225
DIO2-0.222
KCNJ16-0.217
PPP1R3C-0.213

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5696701-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in decreased activity of PIK3C2B protein"21981714
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased activity of PIK3C2B protein"20129775
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3C2B protein20129775
D000082AcetaminophenPIK3C2B gene polymorphism affects the susceptibility to Acetaminophen26104854
D000082AcetaminophenAcetaminophen affects the expression of PIK3C2B mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3C2B mRNA]21233418
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PIK3C2B mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PIK3C2B mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PIK3C2B mRNA"19150397
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3C2B mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PIK3C2B mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of PIK3C2B mRNA23125180
D019327Copper SulfateCopper Sulfate results in decreased expression of PIK3C2B mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PIK3C2B mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PIK3C2B mRNA20106945|2556210
C531198dactolisibdactolisib results in decreased activity of PIK3C2B protein20129775
D003907DexamethasoneDexamethasone results in increased expression of PIK3C2B mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3C2B mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3C2B mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PIK3C2B mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PIK3C2B mRNA27392435
D002945CisplatinCisplatin results in increased expression of PIK3C2B mRNA27392435
D002945CisplatinPIK3C2B results in decreased susceptibility to Cisplatin21986133
C000944dicrotophosdicrotophos results in increased expression of PIK3C2B mRNA28302478
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of PIK3C2B mRNA17490981
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of PIK3C2B mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of PIK3C2B mRNA21233418
D004397FonofosFonofos results in increased methylation of PIK3C2B promoter22847954
D005839GentamicinsGentamicins results in increased expression of PIK3C2B mRNA22061828
C492448ICG 001ICG 001 results in increased expression of PIK3C2B mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3C2B mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3C2B mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIK3C2B mRNA25613284
D007501IronIron deficiency results in increased expression of PIK3C2B mRNA16629162
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3C2B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3C2B mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PIK3C2B mRNA27392435
C544151jinfukangjinfukang results in increased expression of PIK3C2B mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PIK3C2B mRNA24796395
D008727MethotrexatePIK3C2B protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PIK3C2B mRNA28001369
C018620oleoresinsoleoresins results in decreased expression of PIK3C2B mRNA20008804
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PIK3C2B mRNA25729387
D010278ParathionParathion results in increased methylation of PIK3C2B promoter22847954
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PIK3C2B mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of PIK3C2B mRNA24780913
D011794QuercetinQuercetin results in increased expression of PIK3C2B protein19207037
D012906SmokeSmoke results in decreased expression of PIK3C2B mRNA21095227
D018038Sodium SeleniteSodium Selenite results in increased expression of PIK3C2B mRNA18175754
C012568terbufosterbufos results in increased methylation of PIK3C2B promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIK3C2B mRNA26238291
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIK3C2B mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PIK3C2B mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PIK3C2B mRNA25729387
D019772TopotecanTopotecan results in increased expression of PIK3C2B mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PIK3C2B mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PIK3C2B mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of PIK3C2B mRNA28001369
D024483Vitamin K 3Vitamin K 3 affects the expression of PIK3C2B mRNA20044591
C510150ZSTK474ZSTK474 results in decreased activity of PIK3C2B protein20129775

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001727lipid kinase activity-IEA-  
GO:0005515protein binding-IPI10805725  17474147  21706016  22128329  24658140  
GO:0005524ATP binding-IEA-  
GO:00163031-phosphatidylinositol-3-kinase activity-IBA21873635  
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity-IBA21873635  
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity-NAS9830063  
GO:0035091phosphatidylinositol binding-IEA-  
GO:0052742phosphatidylinositol kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0009267cellular response to starvation-IEA-  
GO:0014065phosphatidylinositol 3-kinase signaling-IBA21873635  
GO:0016477cell migration-IBA21873635  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IBA21873635  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0043491protein kinase B signaling-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048015phosphatidylinositol-mediated signaling-IBA21873635  
GO:1905037autophagosome organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
GO:0016020membrane-IBA21873635  
GO:0030139endocytic vesicle-IEA-  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1660499Synthesis of PIPs at the plasma membraneTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal