Gene: LRP1B

53353
LRP-1B|LRP-DIT|LRPDIT
LDL receptor related protein 1B
protein-coding
2q22.1-q22.2
Ensembl:ENSG00000168702 MIM:608766 Vega:OTTHUMG00000131799 UniprotKB:Q9NZR2
NG_051023.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.815e-1 (AD)  6.374e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10928122chr2:141772551 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7558514chr2:141219604 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6429856chr2:141022386 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3923350chr2:140482029 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUT90.787
MEGF90.775
ZNF2920.772
DMD0.771
PCYT1B0.758
LSAMP0.758
PCDH100.753
DYNC2H10.753
TRIP110.753
DBT0.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.44
OR4F29-0.391
TFPI2-0.343
PDE6G-0.327
CLEC6A-0.323
FCRL2-0.315
C19orf33-0.31
CDC42EP5-0.301
TCF15-0.301
KRTAP4-3-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRP1B mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene affects the splicing of LRP1B exon26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRP1B mRNA20106945
C006780bisphenol Abisphenol A results in increased expression of LRP1B mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of LRP1B mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of LRP1B mRNA25979313
D003471CuprizoneCuprizone results in decreased expression of LRP1B mRNA27523638
D003561CytarabineCytarabine results in decreased expression of LRP1B mRNA21198554
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LRP1B mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LRP1B mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRP1B mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LRP1B mRNA29097150
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of LRP1B mRNA24810058
D010269ParaquatParaquat results in increased expression of LRP1B mRNA22563483
C006253pirinixic acidpirinixic acid results in increased expression of LRP1B mRNA18301758
D011441PropylthiouracilPropylthiouracil results in increased expression of LRP1B mRNA24780913
D012834SilverSilver results in decreased expression of LRP1B mRNA27131904
D012999SomanSoman results in decreased expression of LRP1B mRNA19281266
D013629TamoxifenTamoxifen affects the expression of LRP1B mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRP1B mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LRP1B mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRP1B mRNA17942748
D014635Valproic AcidValproic Acid affects the expression of LRP1B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LRP1B mRNA24896083
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LRP1B gene25560391
C025643vinclozolinvinclozolin results in decreased expression of LRP1B mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-TAS10766186  
GO:0015031protein transport-TAS10766186  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18948947Somatic mutations affect key pathways in lung adenocarcinoma. (2008 Oct 23)Ding LNature