Gene: IL20RA

53832
CRF2-8|IL-20R-alpha|IL-20R1|IL-20RA
interleukin 20 receptor subunit alpha
protein-coding
6q23.3
Ensembl:ENSG00000016402 MIM:605620 Vega:OTTHUMG00000015654 UniprotKB:Q9UHF4
NC_000006.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
4.694e-2 (AD)  5.376e-2 (ND)   (Frontal_Cortex)
6.682e-1 (AD)  2.358e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1744061chr6:137003518 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM2200.733
TSPAN60.721
NXT20.693
PPP1R420.69
PDLIM30.689
HSDL20.686
DECR10.68
BDH20.677
PDLIM50.673
ACAA20.67

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.498
SLC36A1-0.496
SSTR3-0.495
TNFAIP8L1-0.492
RTN4RL2-0.49
KCNC3-0.489
RTN4RL1-0.485
OPRD1-0.482
MAPK13-0.482
KCNK9-0.478

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of IL20RA mRNA"20406850
D000082AcetaminophenAcetaminophen affects the expression of IL20RA mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of IL20RA mRNA28522335
D001151ArsenicArsenic affects the methylation of IL20RA gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL20RA mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL20RA mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL20RA mRNA23735875
C075388beta-damascenonebeta-damascenone results in increased expression of IL20RA mRNA22982537
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of IL20RA mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of IL20RA mRNA17404688
C006780bisphenol Abisphenol A affects the expression of IL20RA mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of IL20RA mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IL20RA gene28505145
D002509CephaloridineCephaloridine results in decreased expression of IL20RA mRNA18500788
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of IL20RA mRNA20971185
C039281furanfuran results in increased expression of IL20RA mRNA27387713
D008627Mercuric ChlorideMercuric Chloride results in increased expression of IL20RA mRNA18496552
D009532NickelNickel results in decreased expression of IL20RA mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of IL20RA mRNA20971185
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of IL20RA mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of IL20RA mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IL20RA mRNA17560707|1916217
D010936Plant ExtractsPlant Extracts results in decreased expression of IL20RA mRNA23557933
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of IL20RA mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of IL20RA mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of IL20RA mRNA17404688
C079198S 1 (combination)IL20RA protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IL20RA mRNA25351596
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL20RA mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL20RA mRNA21570461
D014212TretinoinTretinoin results in decreased expression of IL20RA mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of IL20RA mRNA19042947
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL20RA gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0005515protein binding-IPI22802649  
GO:0042015interleukin-20 binding-IBA21873635  
GO:0042015interleukin-20 binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0045124regulation of bone resorption-IEA-  
GO:2001244positive regulation of intrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8854691Interleukin-20 family signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18339850Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. (2008 Mar 15)Tessema MCancer Res