Gene: GDAP1

54332
CMT4|CMT4A|CMTRIA
ganglioside induced differentiation associated protein 1
protein-coding
8q21.11
Ensembl:ENSG00000104381 MIM:606598 Vega:OTTHUMG00000164509 UniprotKB:Q8TB36
NG_008787.3
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.988e-1 (AD)  5.310e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4310196chr8:74360492 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs7846006chr8:74359739 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs9298238chr8:74355383 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOMM200.97
TRAPPC6B0.967
PJA20.966
OLA10.961
DNM1L0.961
UBE2V20.961
UCHL50.96
NAPB0.959
ERLEC10.958
BCAP290.958

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.55
OR4F29-0.537
CSAG1-0.445
EVC2-0.442
RUNX3-0.423
WDR38-0.416
SYDE1-0.408
HEY2-0.406
CNN2-0.405
MAGEA12-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of GDAP1 mRNA19041380
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of GDAP1 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDAP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of GDAP1 mRNA26690555
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GDAP1 mRNA24449571
C015001arsenitearsenite results in increased expression of GDAP1 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of GDAP1 mRNA]18929588
C006780bisphenol Abisphenol A affects the expression of GDAP1 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GDAP1 gene20938992
D003042CocaineCocaine results in increased expression of GDAP1 protein25100957
D003471CuprizoneCuprizone results in decreased expression of GDAP1 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of GDAP1 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GDAP1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of GDAP1 mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of GDAP1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of GDAP1 mRNA18042831
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GDAP1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GDAP1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of GDAP1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of GDAP1 mRNA19167457
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GDAP1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GDAP1 mRNA23649840
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in decreased expression of GDAP1 mRNA23212921
D000073878Palm OilPalm Oil results in decreased expression of GDAP1 mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GDAP1 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of GDAP1 mRNA20813756
D011374ProgesteroneProgesterone results in increased expression of GDAP1 mRNA23018184
D015125OxyquinolineOxyquinoline results in decreased expression of GDAP1 mRNA21632981
C017947sodium arsenitesodium arsenite affects the expression of GDAP1 mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of GDAP1 mRNA22714537
D014212TretinoinTretinoin results in decreased expression of GDAP1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of GDAP1 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GDAP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GDAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GDAP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GDAP1 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0000266mitochondrial fission-IBA21873635  
GO:0000266mitochondrial fission-IDA15772096  
GO:0006626protein targeting to mitochondrion-IBA21873635  
GO:0006626protein targeting to mitochondrion-IMP15772096  
GO:0007005mitochondrion organization-IBA21873635  
GO:0008053mitochondrial fusion-IBA21873635  
GO:0008053mitochondrial fusion-IMP21753178  
GO:0032526response to retinoic acid-IEA-  
GO:0071305cellular response to vitamin D-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0031307integral component of mitochondrial outer membrane-IBA21873635  
GO:0031307integral component of mitochondrial outer membrane-IDA15772096  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers
27128683Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome. (2016 Jun 2)Bruckmann CEpigenetics