Gene: RETREG1

54463
FAM134B|JK-1|JK1
reticulophagy regulator 1
protein-coding
5p15.1
Ensembl:ENSG00000154153 MIM:613114 Vega:OTTHUMG00000161788 UniprotKB:Q9H6L5
NG_016644.2
SNP Mapped
3   ANCO-SNPs
CD|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.793e-2 (AD)  7.816e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs35004chr5:16617794 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs994429chr5:16552290 (GRCh38.p7)T>A / T>Gcocaine dependenceSNV(Single Nucleotide Variation)
rs2115066chr5:16550367 (GRCh38.p7)C>Acocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of RETREG1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RETREG1 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of RETREG1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RETREG1 gene27153756
D000452AldrinAldrin results in decreased expression of RETREG1 mRNA18579281
D000638AmiodaroneAmiodarone affects the expression of RETREG1 mRNA25064622
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RETREG1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RETREG1 mRNA19770486|2222880
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of RETREG1 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of RETREG1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of RETREG1 mRNA23019147|2475840
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of RETREG1 mRNA17404688
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of RETREG1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of RETREG1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of RETREG1 mRNA26496021
D002065BuspironeBuspirone results in increased expression of RETREG1 mRNA24136188
D002220CarbamazepineCarbamazepine affects the expression of RETREG1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RETREG1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RETREG1 mRNA27339419
D002746ChlorpromazineChlorpromazine affects the expression of RETREG1 mRNA25064622
C018021cobaltous chloridecobaltous chloride results in increased expression of RETREG1 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of RETREG1 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of RETREG1 mRNA18579281
D016572CyclosporineCyclosporine affects the expression of RETREG1 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of RETREG1 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of RETREG1 mRNA19770486
D003907DexamethasoneDexamethasone results in increased expression of RETREG1 mRNA25047013
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RETREG1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of RETREG1 mRNA27392435
D004237DiuronDiuron results in decreased expression of RETREG1 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RETREG1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RETREG1 mRNA17555576
C039281furanfuran results in increased expression of RETREG1 mRNA26194646
D005839GentamicinsGentamicins results in decreased expression of RETREG1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of RETREG1 mRNA24136188
D005978GlutathioneGlutathione deficiency results in increased expression of RETREG1 mRNA20621112
D017313FenretinideFenretinide results in increased expression of RETREG1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RETREG1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RETREG1 mRNA27392435
C008261lead acetatelead acetate results in increased expression of RETREG1 mRNA22641619
D064704LevofloxacinLevofloxacin results in increased expression of RETREG1 mRNA24136188
C042720mercuric bromidemercuric bromide results in increased expression of RETREG1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RETREG1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RETREG1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RETREG1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of RETREG1 mRNA24136188
D019829NevirapineNevirapine metabolite results in increased expression of RETREG1 mRNA23947594
D019829NevirapineNevirapine results in increased expression of RETREG1 mRNA23947594
C029938nickel sulfatenickel sulfate results in increased expression of RETREG1 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RETREG1 mRNA25729387
C016030pantogabpantogab results in increased expression of RETREG1 mRNA17379144
D010269ParaquatParaquat affects the expression of RETREG1 mRNA25064622
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of RETREG1 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RETREG1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RETREG1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of RETREG1 mRNA17426115
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of RETREG1 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of RETREG1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of RETREG1 mRNA17404688
C045950propiconazolepropiconazole results in decreased expression of RETREG1 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of RETREG1 mRNA26079696
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA19059307
D015474IsotretinoinIsotretinoin results in decreased expression of RETREG1 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RETREG1 mRNA25895662
C016104sodium bichromatesodium bichromate results in increased expression of RETREG1 mRNA25993096
D053260SootSoot results in increased expression of RETREG1 mRNA26551751
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RETREG1 mRNA"18579281
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of RETREG1 mRNA17555576|2093736
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RETREG1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RETREG1 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RETREG1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RETREG1 mRNA20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RETREG1 mRNA18796159|2121527
D013752TetracyclineTetracycline affects the expression of RETREG1 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RETREG1 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of RETREG1 mRNA25064622
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RETREG1 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of RETREG1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of RETREG1 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RETREG1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RETREG1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RETREG1 mRNA19101580|2317975
C025643vinclozolinvinclozolin results in increased expression of RETREG1 mRNA23034163
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of RETREG1 mRNA18579281
D014810Vitamin EVitamin E results in decreased expression of RETREG1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of RETREG1 mRNA20044591
C088658zoledronic acidzoledronic acid results in increased expression of RETREG1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI26040720  
GO ID GO Term Qualifier Evidence PubMed
GO:0019233sensory perception of pain-IMP19838196  
GO:0043524negative regulation of neuron apoptotic process-IMP26040720  
GO:0061709reticulophagy-IMP26040720  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005801cis-Golgi network-ISS-  
GO:0016604nuclear body-IDA-  
GO:0030176integral component of endoplasmic reticulum membrane-IDA26040720  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal