Gene: ATR

545
FCTCS|FRP1|MEC1|SCKL|SCKL1
ATR serine/threonine kinase
protein-coding
3q23
Ensembl:ENSG00000175054 MIM:601215 Vega:OTTHUMG00000159234 UniprotKB:Q13535
NG_008951.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.620e-1 (AD)  2.367e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7636909chr3:142541720 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPIP5K20.929
TCERG10.924
RINT10.923
TRAPPC110.922
TMX30.92
DOPEY10.917
ABCA50.916
SLC37A30.916
C2CD50.916
TAB30.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.432
OR4F5-0.413
FOXJ1-0.405
RHOD-0.386
MTRNR2L9-0.374
EVC2-0.374
OR4F29-0.371
AKR1C3-0.371
WDR38-0.37
CSAG1-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ATR mRNA"22698814|2890350
C1087311'-(hydroxymethyl)eugenol1'-(hydroxymethyl)eugenol results in increased phosphorylation of ATR protein28818686
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATR mRNA"25510870
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein"26451628
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein modified form"26451628
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein]"26451628
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATR mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATR mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATR mRNA"25510870
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of ATR protein20469912
C0312782-chloroethyl ethyl sulfideATR protein affects the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]19111594
C0312782-chloroethyl ethyl sulfideATR protein affects the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein]19111594
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of ATR protein20469912
C5605803-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased phosphorylation of ATR protein]25269479
C5605803-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [NSC 724998 results in increased phosphorylation of ATR protein]25269479
C0006147253'-oxomethylisoeugenol3'-oxomethylisoeugenol results in increased phosphorylation of ATR protein28818686
C4756224-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine"4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein]"25748550
C4756224-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine"4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased phosphorylation of ATR protein]"25748550
C4756224-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine"4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR"21730979
C4756224-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine"[4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Cisplatin"21730979
C4756224-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine"[4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea"21730979
C4756224-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine"[4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to temozolomide"21730979
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ATR mRNA12419474
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ATR mRNA19191707
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of ATR mRNA26988655
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of ATR mRNA26988655
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of ATR mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of ATR mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of ATR mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ATR mRNA17562736
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein]"26451628
D020106Acrylamide[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide20734998
C016601afimoxifeneATR results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ATR mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ATR gene27153756
C027955aflatoxin G1aflatoxin G1 results in increased activity of ATR protein23907605
C027955aflatoxin G1aflatoxin G1 results in increased expression of ATR protein modified form23907605
C027955aflatoxin G1Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]23907605
C027955aflatoxin G1Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]23907605
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ATR mRNA24449571
D016590Aphidicolin[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased expression of BSCL2 mRNA]22003191
D016590Aphidicolin[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein]22003191
D016590Aphidicolin[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]22003191
D001151ArsenicArsenic affects the methylation of ATR gene25304211
C006632arsenic trioxidearsenic trioxide results in increased activity of ATR protein16891316
C006632arsenic trioxidearsenic trioxide results in increased activity of ATR protein16891316
D001241AspirinAspirin results in decreased expression of ATR mRNA20514442
D001280AtrazineAtrazine results in increased expression of ATR protein26518232
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATR mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of ATR mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ATR mRNA29027980
C006780bisphenol Abisphenol A affects the expression of ATR mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ATR mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATR mRNA26472689
D002110CaffeineCaffeine affects the activity of ATR protein11507241
D002110CaffeineCaffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]18158334
D002110CaffeineCaffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]15975956
D002110CaffeineCaffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]15975956
D002110Caffeine[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide20734998
D002110CaffeineCaffeine results in decreased activity of [ATM protein co-treated with ATR protein]15975956
D002110CaffeineCaffeine results in decreased activity of ATR protein15060176|2073499
D002166Camptothecin3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased phosphorylation of ATR protein]25269479
D002166CamptothecinATR mRNA results in decreased susceptibility to Camptothecin25269479
D002166CamptothecinATR protein results in decreased susceptibility to Camptothecin25269479
D002166CamptothecinCamptothecin results in increased phosphorylation of ATR protein25269479
D002330CarmustineATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]19261750
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AFX protein]25288669
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AFX protein]25288669
C074702chromium hexavalent ionchromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein]16876463
C074702chromium hexavalent ionchromium hexavalent ion results in increased activity of ATR protein16876463
C074702chromium hexavalent ionRAD17 protein affects the reaction [chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein]]16876463
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AFX protein]25288669
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AFX protein]25288669
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ATR mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of ATR mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of ATR mRNA21878529
C030973cupric oxidecupric oxide results in decreased expression of ATR mRNA22077320
D003471CuprizoneCuprizone results in increased expression of ATR mRNA26577399
C114768decamethylcyclopentasiloxanedecamethylcyclopentasiloxane results in decreased expression of ATR mRNA27601420
C014347decitabineATR protein affects the reaction [decitabine results in increased expression of TP53 protein]17977830
C014347decitabinedecitabine affects the localization of ATR protein modified form17991895
C014347decitabinedecitabine promotes the reaction [ATR protein results in increased phosphorylation of TP53 protein]17977830
C014347decitabinedecitabine results in increased activity of ATR protein17977830
C014347decitabineRPA1 protein affects the reaction [decitabine results in increased activity of ATR protein]17977830
C014347decitabinedecitabine results in decreased expression of ATR mRNA27915011
C107676deguelindeguelin results in decreased expression of ATR mRNA22227970
D002945Cisplatin"[4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Cisplatin"21730979
D002945Cisplatin[ATR co-treated with TP53] results in decreased susceptibility to Cisplatin21258400
D002945CisplatinATR results in decreased susceptibility to Cisplatin21652733
D002945CisplatinCisplatin promotes the reaction [MSH2 protein binds to and affects the localization of ATR protein]21285353
D002945CisplatinCisplatin results in decreased expression of ATR mRNA27594783
D002945CisplatinCisplatin results in increased activity of ATR protein21324906
D002945CisplatinERCC6 protein inhibits the reaction [Cisplatin results in increased activity of ATR protein]21324906
D002945Cisplatin[Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA24865317
D002945CisplatinCisplatin results in decreased expression of ATR mRNA24865317
D002945CisplatinCisplatin results in increased phosphorylation of ATR protein22006019
D002945Cisplatin[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased expression of BSCL2 mRNA]22003191
D002945Cisplatin[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]22003191
D002945Cisplatin[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]22003191
D002945CisplatinCisplatin results in increased expression of ATR protein modified form26739623
D002945CisplatinLovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form]26739623
C000944dicrotophosdicrotophos results in decreased expression of ATR mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ATR mRNA26924002
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATR mRNA]19919837
D004052DiethylnitrosamineATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATR protein]19919837
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ATR mRNA19919837
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ATR protein19919837
C024629dimethyl phthalatedimethyl phthalate affects the expression of ATR mRNA26924002
D004317DoxorubicinDoxorubicin results in increased phosphorylation of ATR protein22242153
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATR mRNA22079256
D000431EthanolEthanol results in decreased expression of ATR mRNA29018328
D005047EtoposideEtoposide results in increased phosphorylation of ATR protein22242153
C082360fipronilfipronil results in increased expression of ATR mRNA23962444
D044950FlavanonesFlavanones results in decreased phosphorylation of ATR protein21616090
D005467FloxuridineATR protein results in decreased susceptibility to Floxuridine21613406|2219493
D005707Gallic AcidGallic Acid results in decreased expression of ATR mRNA21887735
D006918Hydroxyurea"[4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea"21730979
D006918HydroxyureaCaffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]18158334
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATR mRNA25613284
D017953IsocyanatesIsocyanates results in increased expression of ATR protein19283680
C544151jinfukangjinfukang results in decreased expression of ATR mRNA27392435
D008148LovastatinLovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form]26739623
D014975Lutein[Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA24865317
D014975LuteinLutein results in decreased expression of ATR mRNA24865317
D008730MethoxsalenMethoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]23907605
C005223methyleugenolmethyleugenol results in increased phosphorylation of ATR protein28818686
C000614724methyleugenol-2',3'-epoxide"methyleugenol-2',3'-epoxide results in increased phosphorylation of ATR protein"28818686
D008770MethylnitrosoureaMethylnitrosourea affects the localization of ATR protein21285353
D008770MethylnitrosoureaMSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein]21285353
D015741MetriboloneATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AFX protein]23272087
D015741MetriboloneMetribolone promotes the reaction [AR protein binds to ATR promoter]19318562
D015741MetriboloneMetribolone promotes the reaction [UXT protein binds to ATR promoter]19318562
D015741MetriboloneMetribolone results in increased expression of ATR mRNA19318562
D015741MetriboloneMetribolone results in increased phosphorylation of ATR protein23272087
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ATR mRNA26924002
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of ATR mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ATR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ATR mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of ATR mRNA27288927
C028007nickel monoxidenickel monoxide analog results in increased phosphorylation of and affects the localization of ATR protein24503009
D009538NicotineNicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form]23907605
C010615Nonidet P-40Nonidet P-40 results in decreased expression of ATR mRNA26552463
C553898NSC 7249983-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [NSC 724998 results in increased phosphorylation of ATR protein]25269479
C553898NSC 724998ATR protein results in decreased susceptibility to NSC 72499825269479
C553898NSC 724998NSC 724998 results in increased phosphorylation of ATR protein25269479
C024064octamethylcyclotetrasiloxaneoctamethylcyclotetrasiloxane results in decreased expression of ATR mRNA27601420
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ATR mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of ATR mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of ATR mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ATR mRNA]17950772
D010936Plant ExtractsPlant Extracts results in increased expression of ATR mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATR mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ATR mRNA22079256
C045950propiconazolepropiconazole results in increased expression of ATR mRNA21278054
D011794QuercetinQuercetin results in increased expression of ATR mRNA21632981
C059514resveratrolCaffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]15975956
C059514resveratrolCaffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]15975956
C059514resveratrolresveratrol results in increased activity of [ATM protein co-treated with ATR protein]15975956
C059514resveratrol[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]15975956
C059514resveratrol[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] which results in increased phosphorylation of H2AFX protein15975956
C547185riccardin Driccardin D results in increased phosphorylation of ATR protein24069304
D012402RotenoneRotenone results in increased expression of ATR mRNA18191903
C015499schizandrin B[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased expression of BSCL2 mRNA]22003191
C015499schizandrin B[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein]22003191
C015499schizandrin B[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]22003191
C015499schizandrin B[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased expression of BSCL2 mRNA]22003191
C015499schizandrin B[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]22003191
C015499schizandrin B[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]22003191
C015499schizandrin Bschizandrin B results in decreased activity of ATR protein22003191
D012834SilverSilver affects the expression of ATR mRNA19429238
D012835Silver NitrateSilver Nitrate analog results in increased expression of ATR mRNA22831968
C017947sodium arsenitesodium arsenite affects the methylation of ATR gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of ATR protein23618899
D013241SterigmatocystinATR protein promotes the reaction [Sterigmatocystin results in increased phosphorylation of CHEK1 protein]26914363
D013241SterigmatocystinSterigmatocystin results in increased phosphorylation of ATR protein26914363
C047246temozolomide"[4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to temozolomide"21730979
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATR mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ATR mRNA23411599
C523062thio-dimethylarsinatethio-dimethylarsinate results in increased expression of ATR mRNA27320638
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ATR mRNA27404394|2786577
C080163trovafloxacin"4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein]"25748550
C080163trovafloxacin"4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased phosphorylation of ATR protein]"25748550
C080163trovafloxacin[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of and results in increased activity of ATR protein25748550
C080163trovafloxacintrovafloxacin results in increased phosphorylation of and results in increased activity of ATR protein25748550
C080163trovafloxacinU 0126 inhibits the reaction [trovafloxacin results in increased activity of ATR protein]25748550
C113580U 0126U 0126 inhibits the reaction [trovafloxacin results in increased activity of ATR protein]25748550
C113580U 0126U 0126 results in decreased activity of ATR protein25748550
D014520UrethaneUrethane results in decreased expression of ATR mRNA28818685
D014527Uric AcidNLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein]23619996
D014527Uric AcidUric Acid results in increased phosphorylation of ATR protein23619996
D014635Valproic AcidValproic Acid results in increased expression of ATR mRNA23179753
C009687wortmanninwortmannin results in decreased activity of ATR protein22119920
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA16357179
D019345Zinc AcetateZinc Acetate results in decreased expression of ATR mRNA16357179
C023616zinc chromatezinc chromate results in increased phosphorylation of ATR protein19027772

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0004672protein kinase activity-IDA14657349  
GO:0004674protein serine/threonine kinase activity-IDA9733515  9925639  27723717  27723720  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI14657349  17686975  18583959  19633697  19889979  20616048  
20810650  20864032  20930849  27723717  27723720  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IBA21873635  
GO:0032405MutLalpha complex binding-IDA16713580  
GO:0032407MutSalpha complex binding-IDA16713580  
GO ID GO Term Qualifier Evidence PubMed
GO:0000077DNA damage checkpoint-IDA14657349  
GO:0006260DNA replication-TAS-  
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-TAS8610130  
GO:0006974cellular response to DNA damage stimulus-IDA27723717  27723720  
GO:0006974cellular response to DNA damage stimulus-TAS15538388  
GO:0007275multicellular organism development-TAS9590286  
GO:0008156negative regulation of DNA replication-IMP14657349  
GO:0018105peptidyl-serine phosphorylation-IDA9733515  
GO:0032212positive regulation of telomere maintenance via telomerase-ISS-  
GO:0034644cellular response to UV-IMP9925639  
GO:0036297interstrand cross-link repair-TAS-  
GO:0042493response to drug-IEA-  
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator-IMP9925639  
GO:0046777protein autophosphorylation-IDA9733515  
GO:0070198protein localization to chromosome, telomeric region-IMP21829167  
GO:0071480cellular response to gamma radiation-IDA9925639  
GO:0090399replicative senescence-IMP15149599  
GO:0097694establishment of RNA localization to telomere-IMP26586433  
GO:0097695establishment of protein-containing complex localization to telomere-IC26586433  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1904884positive regulation of telomerase catalytic core complex assembly-IMP26586433  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withIC26586433  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-ISS-  
GO:0005794Golgi apparatus-IDA-  
GO:0016605PML body-IDA12814551  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27855115Infrared analysis of lipoproteins in the detection of alcohol biomarkers. (2017 May 1)De Bruyne SClin Chem Lab Med
23197179Evaluation of digital thermal monitoring as a tool to assess perioperative vascular reactivity. (2013)Schier RJ Atheroscler Thromb
26288303[Duration of therapeutic remission alcohol dependence: a role of dopamine system genes polymorphism and family history density]. (2015)Kibitov AOZh Nevrol Psikhiatr Im S S Korsakova
26599135Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2/3 receptor blockade. (2016 Mar)Ebdrup BHJ Psychiatry Neurosci
11393670Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease. (2001 May)Olivieri OJ Hypertens
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
28662958Targeting ATR in cancer medicine. (2017 Jul - Aug)Sundar RCurr Probl Cancer