Gene: RBFOX1

54715
2BP1|A2BP1|FOX-1|FOX1|HRNBP1
RNA binding fox-1 homolog 1
protein-coding
16p13.3
Ensembl:ENSG00000078328 MIM:605104 Vega:OTTHUMG00000129551 UniprotKB:Q9NWB1
NG_011881.1
PubMed|SNP Mapped
16   ANCO-SNPs
CD|ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.701e-2 (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1507030chr16:7561154 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs11641647chr16:7144839 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1904224chr16:7141865 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs922471chr16:7140896 (GRCh38.p7)G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4444357chr16:7140074 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11863081chr16:7139575 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs35269146chr16:7139413 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs8047522chr16:7139410 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs8052094chr16:7138545 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6500918chr16:7136901 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1871256chr16:7130063 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11077139chr16:7124873 (GRCh38.p7)C>A / C>Galcohol dependenceSNV(Single Nucleotide Variation)
rs35569480chr16:7105447 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12932935chr16:6475759 (GRCh38.p7)T>Gcocaine dependenceSNV(Single Nucleotide Variation)
rs17192650chr16:6066395 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17138815chr16:5901423 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNQ50.984
GABRB20.978
ADAM230.978
NMNAT20.977
ADD20.976
NSF0.976
SYT10.976
GABRG20.975
MAP7D20.975
CNKSR20.975

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.553
MYL3-0.553
TFPI2-0.541
CNN2-0.537
HEY2-0.535
WWTR1-0.531
RAI14-0.528
RUNX3-0.526
RAB13-0.526
RNF135-0.524

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of RBFOX1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RBFOX1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RBFOX1 gene27153756
D016604Aflatoxin B1RBFOX1 gene SNP affects the susceptibility to Aflatoxin B125622337
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RBFOX1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of RBFOX1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of RBFOX1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RBFOX1 gene28505145
D003471CuprizoneCuprizone results in decreased expression of RBFOX1 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RBFOX1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RBFOX1 mRNA17361019
D004041Dietary FatsDietary Fats results in decreased expression of RBFOX1 mRNA25016146
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RBFOX1 mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of RBFOX1 mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RBFOX1 protein23301498
D007608Kainic AcidRBFOX1 gene mutant form results in increased susceptibility to Kainic Acid21623373
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RBFOX1 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RBFOX1 mRNA26011545
D008774MethylphenidateMethylphenidate results in increased expression of RBFOX1 mRNA22470460
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of RBFOX1 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RBFOX1 mRNA26272509
C531249Poly(amidoamine)Poly(amidoamine) analog results in decreased expression of RBFOX1 mRNA23806026
D011441PropylthiouracilPropylthiouracil results in decreased expression of RBFOX1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RBFOX1 mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of RBFOX1 gene28589171
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RBFOX1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RBFOX1 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RBFOX1 mRNA19933214
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RBFOX1 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of RBFOX1 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of RBFOX1 mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of RBFOX1 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased expression of RBFOX1 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RBFOX1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RBFOX1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RBFOX1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RBFOX1 gene25560391
D024483Vitamin K 3RBFOX1 affects the susceptibility to Vitamin K 322715409

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-NAS10814712  
GO:0003729mRNA binding-IBA21873635  
GO:0005515protein binding-IPI16713569  25416956  
GO:0008022protein C-terminus binding-IPI10814712  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0006397mRNA processing-IEA-  
GO:0007399nervous system development-IBA21873635  
GO:0008380RNA splicing-IEA-  
GO:0050658RNA transport-NAS10814712  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA10814712  
GO:0005802trans-Golgi network-IDA10814712  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27164557Genetic Relationship between Schizophrenia and Nicotine Dependence. (2016 May 10)Chen JSci Rep