Gene: TMEM104

54868
-
transmembrane protein 104
protein-coding
17q25.1
Ensembl:ENSG00000109066 Vega:OTTHUMG00000179025 UniprotKB:Q8NE00
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.892e-2 (AD)  5.756e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16978197chr17:74812508 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SORCS20.861
PLXNB10.853
SLC27A10.851
DAG10.841
NEO10.834
SLC44A20.831
SCAMP40.827
CASKIN20.825
SLC48A10.819
SEMA4B0.817

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.506
OR4F29-0.467
SCARA5-0.324
C17orf112-0.302
GADL1-0.298
BMP5-0.289
FER1L6-0.281
CETP-0.275
SULT2B1-0.272
LCE2A-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of TMEM104 mRNA22230336
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMEM104 mRNA20064835|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEM104 mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of TMEM104 mRNA25047013
C006780bisphenol Abisphenol A results in decreased methylation of TMEM104 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of TMEM104 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TMEM104 gene28505145
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of TMEM104 mRNA26033743
D003300CopperCopper deficiency results in increased expression of TMEM104 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of TMEM104 mRNA27523638
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TMEM104 mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of TMEM104 mRNA28302478
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of TMEM104 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of TMEM104 mRNA26033743
D007213IndomethacinIndomethacin results in increased expression of TMEM104 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TMEM104 mRNA25613284
D007854LeadLead affects the expression of TMEM104 mRNA28903495
D008777MethyltestosteroneMethyltestosterone results in increased expression of TMEM104 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TMEM104 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TMEM104 mRNA"25554681
D012834SilverSilver results in decreased expression of TMEM104 mRNA27131904
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TMEM104 mRNA25613284
D014212TretinoinTretinoin results in increased expression of TMEM104 mRNA23724009
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMEM104 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal