Gene: IMPAD1

54928
GPAPP|IMP 3|IMP-3|IMPA3
inositol monophosphatase domain containing 1
protein-coding
8q12.1
Ensembl:ENSG00000104331 MIM:614010 Vega:OTTHUMG00000164415 UniprotKB:Q9NX62
NG_031926.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.799e-1 (AD)  2.353e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs36065736chr8:56985796 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARL10.965
CDC270.962
ATAD10.957
MARCH60.957
ANKRD13C0.955
NARS0.955
CUL30.953
OPA10.951
RAB140.95
ZDHHC170.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.64
OR4F29-0.599
CSAG1-0.384
MTRNR2L9-0.378
MTRNR2L6-0.369
MTRNR2L10-0.359
MTRNR2L2-0.331
MTRNR2L8-0.317
TTLL10-0.312
PPBP-0.31

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of IMPAD1 mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IMPAD1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IMPAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IMPAD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IMPAD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IMPAD1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of IMPAD1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of IMPAD1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IMPAD1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of IMPAD1 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of IMPAD1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IMPAD1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IMPAD1 mRNA22300585
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IMPAD1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of IMPAD1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IMPAD1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of IMPAD1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IMPAD1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of IMPAD1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of IMPAD1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IMPAD1 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IMPAD1 mRNA20938992
D003561CytarabineCytarabine results in decreased expression of IMPAD1 mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IMPAD1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IMPAD1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IMPAD1 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of IMPAD1 mRNA27594783
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of IMPAD1 mRNA27638505
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IMPAD1 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IMPAD1 mRNA23649840
D005485FlutamideFlutamide results in increased expression of IMPAD1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IMPAD1 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of IMPAD1 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IMPAD1 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IMPAD1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IMPAD1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IMPAD1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of IMPAD1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IMPAD1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of IMPAD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IMPAD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IMPAD1 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of IMPAD1 mRNA27392435
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IMPAD1 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IMPAD1 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IMPAD1 mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of IMPAD1 mRNA29191790
C028473N-acetyl-4-benzoquinoneimineIMPAD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
C051752nefazodonenefazodone results in increased expression of IMPAD1 mRNA24136188
D009532NickelNickel results in increased expression of IMPAD1 mRNA24768652|2558310
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of IMPAD1 mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of IMPAD1 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IMPAD1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IMPAD1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of IMPAD1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IMPAD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of IMPAD1 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of IMPAD1 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of IMPAD1 mRNA21278054
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IMPAD1 mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of IMPAD1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of IMPAD1 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of IMPAD1 mRNA28595984
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IMPAD1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IMPAD1 mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IMPAD1 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IMPAD1 mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of IMPAD1 mRNA17982090
C057693troglitazonetroglitazone results in decreased expression of IMPAD1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IMPAD1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of IMPAD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of IMPAD1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of IMPAD1 mRNA17292431
C025643vinclozolinvinclozolin affects the expression of IMPAD1 mRNA19015723
D002762CholecalciferolCholecalciferol results in increased expression of IMPAD1 mRNA16508948

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00082543'-nucleotidase activity-IBA21873635  
GO:00082543'-nucleotidase activity-IEA-  
GO:00084413'(2'),5'-bisphosphate nucleotidase activity-TAS-  
GO:0008934inositol monophosphate 1-phosphatase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0052832inositol monophosphate 3-phosphatase activity-IEA-  
GO:0052833inositol monophosphate 4-phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IBA21873635  
GO:0001958endochondral ossification-IEA-  
GO:0002063chondrocyte development-IEA-  
GO:0006021inositol biosynthetic process-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0030204chondroitin sulfate metabolic process-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005794Golgi apparatus-IDA18695242  
GO:0005796Golgi lumen-TAS-  
GO:0005829cytosol-IDA-  
GO:0012505endomembrane system-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156584Cytosolic sulfonation of small moleculesTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal