Gene: SOBP

55084
JXC1|MRAMS
sine oculis binding protein homolog
protein-coding
6q21
Ensembl:ENSG00000112320 MIM:613667 Vega:OTTHUMG00000015312 UniprotKB:A7XYQ1
NG_028200.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.104e-1 (AD)  2.214e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7775895chr6:107565318 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEPT30.943
WSB20.94
CALM10.938
PIP4K2B0.937
CDK160.934
RAB11FIP30.934
VAMP20.932
C6orf1060.932
CALM30.926
BRSK10.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.682
OR4F29-0.658
CXCR2-0.428
TFPI2-0.415
C1orf87-0.415
KCNJ15-0.409
CCR2-0.408
IL18RAP-0.408
FCGR3B-0.401
TNFRSF10C-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SOBP mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SOBP gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SOBP mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of SOBP mRNA26377693
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of SOBP mRNA]24758408
D004958EstradiolEstradiol results in increased expression of SOBP mRNA24758408
C006780bisphenol Abisphenol A results in increased expression of SOBP mRNA25047013
C006780bisphenol Abisphenol A affects the expression of SOBP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SOBP gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SOBP mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SOBP mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of SOBP mRNA26079696
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SOBP mRNA24763279
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SOBP mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOBP gene20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SOBP mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SOBP mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SOBP mRNA25562108|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SOBP mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SOBP mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SOBP mRNA27392435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOBP gene20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SOBP mRNA24763279
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SOBP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SOBP mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SOBP mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SOBP mRNA27392435
D007854LeadLead results in decreased expression of SOBP mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of SOBP mRNA"24972896
C042720mercuric bromidemercuric bromide results in decreased expression of SOBP mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SOBP gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SOBP mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SOBP mRNA23179753|2718838
D009532NickelNickel results in decreased expression of SOBP mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of SOBP mRNA19167457
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of SOBP mRNA19074003
C570897NSC668394NSC668394 results in decreased expression of SOBP mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SOBP mRNA20971185
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of SOBP mRNA21503142
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SOBP mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SOBP mRNA21061450
D010936Plant ExtractsPlant Extracts results in decreased expression of SOBP mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SOBP mRNA23608068
D011794QuercetinQuercetin results in decreased expression of SOBP mRNA21632981
D012643SeleniumSelenium results in decreased expression of SOBP mRNA19244175
D053260SootSoot results in decreased expression of SOBP mRNA26551751
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of SOBP mRNA19074003
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SOBP mRNA25172293
C009495titanium dioxidetitanium dioxide results in decreased expression of SOBP mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SOBP mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOBP mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SOBP mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of SOBP mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SOBP mRNA19042947
D014520UrethaneUrethane results in increased expression of SOBP mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of SOBP mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SOBP mRNA19101580|2493525
D014635Valproic AcidValproic Acid results in increased methylation of SOBP gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SOBP gene25560391
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of SOBP mRNA21503142
C025643vinclozolinvinclozolin affects the expression of SOBP mRNA19015723
D014750VincristineVincristine results in decreased expression of SOBP mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of SOBP mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0032184SUMO polymer binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007605sensory perception of sound-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0042472inner ear morphogenesis-IEA-  
GO:0050890cognition-IMP21035105  
GO:0090102cochlea development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal