Gene: ANO10

55129
SCAR10|TMEM16K
anoctamin 10
protein-coding
3p22.1-p21.33
Ensembl:ENSG00000160746 MIM:613726 Vega:OTTHUMG00000133044 UniprotKB:Q9NW15
NG_028216.2
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.430e-1 (AD)  3.309e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2888312chr3:43443475 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11710107chr3:43432422 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGED20.908
RPA10.901
PPT10.897
MTHFD10.897
VCP0.896
C6orf890.894
DDB10.893
GANAB0.892
APLP20.89
TMEM2480.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.698
OR4F29-0.655
MTRNR2L6-0.38
MTRNR2L9-0.365
MTRNR2L10-0.329
TTLL10-0.297
MTRNR2L2-0.255
PPBP-0.245
CTNNA3-0.245
MTRNR2L3-0.243

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANO10 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANO10 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANO10 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANO10 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANO10 mRNA"25510870
C0293704-toluidine4-toluidine results in increased expression of ANO10 mRNA27638505
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ANO10 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of ANO10 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ANO10 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of ANO10 mRNA20977926
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO10 mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ANO10 mRNA20971185
C029892cupric chloridecupric chloride results in decreased expression of ANO10 mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of ANO10 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ANO10 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ANO10 mRNA27594783
D004026DieldrinDieldrin results in decreased expression of ANO10 mRNA28385952
D002117CalcitriolCalcitriol results in increased expression of ANO10 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ANO10 mRNA21592394
D000431EthanolEthanol results in increased expression of ANO10 mRNA28986285
D018120FinasterideFinasteride results in increased expression of ANO10 mRNA24136188
D005485FlutamideFlutamide results in increased expression of ANO10 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO10 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ANO10 mRNA23649840
D017313FenretinideFenretinide results in decreased expression of ANO10 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANO10 mRNA25613284
D048628KetolidesKetolides analog results in increased expression of ANO10 mRNA24967691
C045463leflunomideleflunomide results in increased expression of ANO10 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO10 mRNA20938992
C051752nefazodonenefazodone results in increased expression of ANO10 mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of ANO10 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ANO10 mRNA20971185
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANO10 mRNA"25510870
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ANO10 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ANO10 mRNA19482888
D011374ProgesteroneProgesterone results in decreased expression of ANO10 mRNA23012394
D015474IsotretinoinIsotretinoin results in decreased expression of ANO10 mRNA20436886
C017947sodium arsenitesodium arsenite affects the expression of ANO10 mRNA19590694
C016104sodium bichromatesodium bichromate results in decreased expression of ANO10 mRNA17685462
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ANO10 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ANO10 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANO10 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANO10 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANO10 mRNA25613284
D014520UrethaneUrethane results in increased expression of ANO10 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of ANO10 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ANO10 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005227calcium activated cation channel activity-IDA22946059  
GO:0005229intracellular calcium activated chloride channel activity-IDA22946059  
GO:0005229intracellular calcium activated chloride channel activityNOTIDA21984732  
GO:0005229intracellular calcium activated chloride channel activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-IDA22946059  
GO:0006821chloride transport-IDA22946059  
GO:0034220ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA22075693  
GO:0005886plasma membrane-IDA22946059  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal