Gene: ARHGEF10L

55160
GrinchGEF
Rho guanine nucleotide exchange factor 10 like
protein-coding
1p36.13
Ensembl:ENSG00000074964 MIM:612494 Vega:OTTHUMG00000002514 UniprotKB:Q9HCE6
NG_050860.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.712e-2 (AD)  7.119e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2477735chr1:17542684 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18641151chr1:17866039ARHGEF10LPromoter3.370e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDXK0.865
TRAF70.858
TAPBP0.852
REPIN10.847
WIZ0.847
B4GALNT40.846
DAB2IP0.845
PRRC2A0.845
TMEM132A0.844
TFE30.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.691
OR4F29-0.617
OR6C74-0.367
CETP-0.349
CTNNA3-0.332
KRTAP1-1-0.327
CNTF-0.321
FCRL1-0.308
CLEC6A-0.304
CEACAM3-0.304

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of ARHGEF10L mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ARHGEF10L mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of ARHGEF10L mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ARHGEF10L mRNA24449571
D001151ArsenicArsenic affects the methylation of ARHGEF10L gene25304211
D001280AtrazineAtrazine results in increased expression of ARHGEF10L mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of ARHGEF10L mRNA26063408
C018475butyraldehydebutyraldehyde results in decreased expression of ARHGEF10L mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of ARHGEF10L mRNA25979313
D019327Copper SulfateCopper Sulfate results in decreased expression of ARHGEF10L mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ARHGEF10L mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased methylation of ARHGEF10L promoter27989131
D003976DiazinonDiazinon results in increased methylation of ARHGEF10L gene22964155
D004041Dietary FatsDietary Fats results in increased expression of ARHGEF10L mRNA18042831
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARHGEF10L mRNA"25620056
D000073878Palm OilPalm Oil results in increased expression of ARHGEF10L mRNA18042831
C006253pirinixic acidpirinixic acid results in decreased expression of ARHGEF10L mRNA23811191
C017947sodium arsenitesodium arsenite affects the methylation of ARHGEF10L gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGEF10L mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ARHGEF10L mRNA25975270
D014212TretinoinTretinoin results in increased expression of ARHGEF10L mRNA23830798
D014635Valproic AcidValproic Acid affects the expression of ARHGEF10L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ARHGEF10L mRNA28001369|2915479
D014635Valproic AcidValproic Acid affects the expression of ARHGEF10L mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARHGEF10L gene25560391
C111237vorinostatvorinostat results in decreased expression of ARHGEF10L mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IBA21873635  
GO:0005089Rho guanyl-nucleotide exchange factor activity-IBA21873635  
GO:0005089Rho guanyl-nucleotide exchange factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0032933SREBP signaling pathway-IBA21873635  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0051496positive regulation of stress fiber assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal