Gene: LINS1

55180
LINS|MRT27|WINS1
lines homolog 1
protein-coding
15q26.3
Ensembl:ENSG00000140471 MIM:610350 Vega:OTTHUMG00000149865 UniprotKB:Q8NG48
NG_034076.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.706e-2 (AD)  1.122e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4965678chr15:100575243 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1493652chr15:100572137 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3764198chr15:100570360 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LINS1 mRNA"19114083
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LINS1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LINS1 mRNA22228805
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of LINS1 mRNA26496021
D002330CarmustineLINS1 mRNA affects the susceptibility to Carmustine16365179
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of LINS1 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of LINS1 mRNA20655997
C045463leflunomideleflunomide results in increased expression of LINS1 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LINS1 mRNA23649840
D009532NickelNickel results in increased expression of LINS1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of LINS1 mRNA16780908
D010936Plant ExtractsPlant Extracts results in increased expression of LINS1 mRNA23557933
C047246temozolomideLINS1 mRNA affects the susceptibility to temozolomide16365179
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of LINS1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LINS1 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of LINS1 mRNA23411599
C483909torcetrapibtorcetrapib results in increased expression of LINS1 mRNA23228038
D014635Valproic AcidValproic Acid results in decreased expression of LINS1 mRNA23179753
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of LINS1 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LINS1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of LINS1 mRNA23555832
C088658zoledronic acidzoledronic acid results in increased expression of LINS1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0050890cognition-IMP23773660  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal