Gene: ZNF532

55205
-
zinc finger protein 532
protein-coding
18q21.32
Ensembl:ENSG00000074657 Vega:OTTHUMG00000132759 UniprotKB:Q9HCE3
NC_000018.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.472e-2 (AD)  4.223e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7245090chr18:58968091 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs17761525chr18:58911721 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP240.866
PKD20.86
PNN0.858
GOLGA10.856
BPTF0.853
ANKHD10.852
SNX190.847
BAZ2A0.846
SNX10.846
SF3B10.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.66
OR4F5-0.653
PAGE4-0.199
HCRT-0.192
OXT-0.18
AVP-0.179
HMX2-0.177
LHX9-0.177
FOXB1-0.177
C22orf42-0.174

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ZNF532 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF532 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF532 mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZNF532 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of ZNF532 mRNA22378314
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ZNF532 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ZNF532 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ZNF532 mRNA26079696
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ZNF532 mRNA28628672
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ZNF532 mRNA23649840
D005472FluorouracilZNF532 protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in increased expression of ZNF532 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ZNF532 mRNA26846883
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ZNF532 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ZNF532 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZNF532 mRNA24435446|2479639
D008627Mercuric ChlorideMercuric Chloride affects the expression of ZNF532 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZNF532 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZNF532 mRNA26011545
C046012pentanalpentanal results in decreased expression of ZNF532 mRNA26079696
D011374ProgesteroneProgesterone results in decreased expression of ZNF532 mRNA18070364
D015474IsotretinoinIsotretinoin results in increased expression of ZNF532 mRNA20436886
D012524SarinSarin results in decreased expression of ZNF532 mRNA19522546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZNF532 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZNF532 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ZNF532 mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF532 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ZNF532 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in decreased expression of ZNF532 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased expression of ZNF532 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal