Gene: SETD5

55209
-
SET domain containing 5
protein-coding
3p25.3
Ensembl:ENSG00000168137 MIM:615743 Vega:OTTHUMG00000150491 UniprotKB:Q9C0A6
NG_034132.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.745e-1 (AD)  8.923e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11922615chr3:9416623 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6443238chr3:9407371 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAZ2A0.929
ASXL10.924
EP4000.917
DCAF50.913
TNRC6A0.91
SRRM20.906
TTC170.903
KDM2A0.901
CCDC930.901
UBR40.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.607
OR4F29-0.571
KLRC2-0.3
PAGE4-0.274
TRDN-0.252
NANOGNB-0.251
GSDMC-0.248
SIM1-0.248
IAPP-0.247
FOXB1-0.247

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SETD5 mRNA12958071
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SETD5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SETD5 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SETD5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SETD5 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SETD5 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of SETD5 mRNA22323515
D001554BenzeneBenzene results in increased expression of SETD5 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SETD5 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SETD5 mRNA"19150397
D001599BerberineBerberine results in increased expression of SETD5 mRNA27311644
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SETD5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SETD5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SETD5 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD5 mRNA28628672
C099555CD 437CD 437 results in increased expression of SETD5 mRNA12958071
D002737ChloropreneChloroprene results in increased expression of SETD5 mRNA23125180
D019327Copper SulfateCopper Sulfate results in increased expression of SETD5 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SETD5 mRNA20106945
D016572CyclosporineCyclosporine results in increased methylation of SETD5 promoter27989131
D003703DemecolcineDemecolcine results in increased expression of SETD5 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SETD5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD5 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of SETD5 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of SETD5 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SETD5 mRNA"22485181
D004237DiuronDiuron results in decreased expression of SETD5 mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of SETD5 mRNA"23811387
C082360fipronilfipronil results in decreased expression of SETD5 mRNA23962444
D005472FluorouracilFluorouracil affects the expression of SETD5 mRNA16584549
D005557FormaldehydeFormaldehyde results in decreased expression of SETD5 mRNA20655997
C069837fullerene C60fullerene C60 results in increased expression of SETD5 mRNA19167457
D017313FenretinideFenretinide results in increased expression of SETD5 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SETD5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SETD5 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of SETD5 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SETD5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SETD5 mRNA28628672
D007854LeadLead results in increased expression of SETD5 mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SETD5 mRNA28001369
C059539midostaurinmidostaurin results in increased expression of SETD5 mRNA20980353
D009151Mustard GasMustard Gas results in decreased expression of SETD5 mRNA26392148
D009285NaphthoquinonesNaphthoquinones results in increased expression of SETD5 mRNA23811387
C028007nickel monoxidenickel monoxide results in increased expression of SETD5 mRNA19167457
C006253pirinixic acidpirinixic acid results in increased expression of SETD5 mRNA18301758
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of SETD5 mRNA21334430
D011374ProgesteroneProgesterone results in increased expression of SETD5 mRNA19690047
D011794QuercetinQuercetin results in increased expression of SETD5 mRNA21632981
C010327salinomycinsalinomycin results in decreased expression of SETD5 mRNA19682730
C009277sodium arsenatesodium arsenate results in increased expression of SETD5 mRNA21795629
D018038Sodium SeleniteSodium Selenite results in decreased expression of SETD5 mRNA18175754
D012999SomanSoman results in increased expression of SETD5 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SETD5 mRNA27914987
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SETD5 mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SETD5 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SETD5 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in decreased expression of SETD5 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of SETD5 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SETD5 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SETD5 gene25560391
C025643vinclozolinvinclozolin affects the expression of SETD5 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0016569covalent chromatin modification-ISS-  
GO:0035065regulation of histone acetylation-ISS-  
GO:1902275regulation of chromatin organization-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0016593Cdc73/Paf1 complexcolocalizes_withISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal