Gene: PPP2R2B

5521
B55BETA|PP2AB55BETA|PP2ABBETA|PP2APR55B|PP2APR55BETA|PR2AB55BETA|PR2ABBETA|PR2APR55BETA|PR52B|PR55-BETA|PR55BETA|SCA12
protein phosphatase 2 regulatory subunit Bbeta
protein-coding
5q32
Ensembl:ENSG00000156475 MIM:604325 Vega:OTTHUMG00000163381 UniprotKB:Q00005
NG_011570.1
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  1.414e-1 (ND)   (Frontal_Cortex)
1.837e-1 (AD)  3.972e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1864982chr5:146941260 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10037107chr5:146849539 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1E10.97
MDH10.964
PFN20.963
RTN30.962
ATP6AP20.961
ATP6V1D0.961
OCIAD10.961
REEP50.96
RTN40.958
OAT0.958

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.678
OR4F29-0.649
CSAG1-0.431
TFPI2-0.42
CNN2-0.411
MTRNR2L6-0.409
RUNX3-0.409
MTRNR2L10-0.4
MAGEA12-0.4
MTRNR2L9-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PPP2R2B mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PPP2R2B mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPP2R2B mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PPP2R2B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PPP2R2B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of PPP2R2B mRNA"16984957
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PPP2R2B mRNA"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPP2R2B mRNA]12710931
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PPP2R2B mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PPP2R2B mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of PPP2R2B mRNA25088246
C0299552-nitrotoluene2-nitrotoluene results in increased expression of PPP2R2B mRNA16460773
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of PPP2R2B mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PPP2R2B mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPP2R2B mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PPP2R2B gene27153756
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA17785943
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPP2R2B mRNA16483693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP2R2B mRNA"19150397
D004958EstradiolEstradiol results in increased expression of PPP2R2B mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of PPP2R2B mRNA24534842
C006780bisphenol Abisphenol A results in decreased expression of PPP2R2B mRNA25181051
C025703bleomycetinbleomycetin results in increased expression of PPP2R2B mRNA21040473
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of PPP2R2B mRNA16460773
C018475butyraldehydebutyraldehyde results in increased expression of PPP2R2B mRNA26079696
D002110CaffeineCaffeine results in decreased expression of PPP2R2B mRNA18444173
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PPP2R2B mRNA26272509
D003042CocaineCocaine affects the expression of PPP2R2B mRNA20187946
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of PPP2R2B mRNA24690739
D003345CorticosteroneCorticosterone results in decreased expression of PPP2R2B mRNA15755911
C014347decitabinedecitabine affects the expression of PPP2R2B mRNA23300844
D002945CisplatinCisplatin affects the expression of PPP2R2B mRNA23300844
D002945CisplatinCisplatin results in increased expression of PPP2R2B mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PPP2R2B mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of PPP2R2B mRNA17005392
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PPP2R2B mRNA"19480007
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of PPP2R2B mRNA24690739
D004237DiuronDiuron results in decreased expression of PPP2R2B mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PPP2R2B mRNA15834898|1755790
D019833GenisteinGenistein results in increased expression of PPP2R2B mRNA18444173
C412815GW 4064GW 4064 results in decreased expression of PPP2R2B mRNA26655953
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PPP2R2B mRNA25307878
D007657Ketone BodiesKetone Bodies results in decreased expression of PPP2R2B mRNA16807920
D007854LeadLead affects the expression of PPP2R2B mRNA28903495
D001556LindaneLindane results in decreased expression of PPP2R2B mRNA17785943
D008558MelphalanMelphalan results in decreased expression of PPP2R2B mRNA22363485
C042720mercuric bromidemercuric bromide results in decreased expression of PPP2R2B mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PPP2R2B mRNA23179753|2627250
D0156551-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPP2R2B mRNA]12710931
C523799MRK 003MRK 003 results in decreased expression of PPP2R2B mRNA21169257
C523799MRK 003PPP2R2B results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PPP2R2B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PPP2R2B mRNA"25554681
D019829NevirapineNevirapine metabolite results in decreased expression of PPP2R2B mRNA23947594
D019829NevirapineNevirapine results in decreased expression of PPP2R2B mRNA23947594
D009534NiclosamideNiclosamide results in decreased expression of PPP2R2B mRNA22576131
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of PPP2R2B mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PPP2R2B mRNA"25510870
C046012pentanalpentanal results in increased expression of PPP2R2B mRNA26079696
D010575PesticidesPesticides results in increased methylation of PPP2R2B gene28396702
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PPP2R2B mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PPP2R2B mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PPP2R2B mRNA19162173
D011374ProgesteroneProgesterone affects the expression of PPP2R2B mRNA17251523
D011374ProgesteroneProgesterone results in decreased expression of PPP2R2B mRNA17556502|2223828
D011441PropylthiouracilPropylthiouracil results in increased expression of PPP2R2B mRNA24780913
D012402RotenoneRotenone results in decreased expression of PPP2R2B mRNA23186747
D012402RotenoneRotenone affects the localization of PPP2R2B protein18940801
D012969Sodium FluorideSodium Fluoride results in decreased expression of PPP2R2B mRNA21340527
D012969Sodium FluorideSodium Fluoride results in increased expression of PPP2R2B mRNA27257137
D053260SootSoot results in decreased expression of PPP2R2B mRNA26551751
D019311StaurosporineStaurosporine affects the localization of PPP2R2B protein18940801
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPP2R2B mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPP2R2B mRNA16922920
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPP2R2B mRNA22298810
D014212TretinoinTretinoin results in increased expression of PPP2R2B mRNA16249480|2372400
C032910triadimefontriadimefon results in increased expression of PPP2R2B mRNA26705709
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP2R2B mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PPP2R2B mRNA26272509
D014415TunicamycinTunicamycin affects the localization of PPP2R2B protein18940801
D014635Valproic AcidValproic Acid results in increased expression of PPP2R2B mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PPP2R2B gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PPP2R2B mRNA26682919
C088658zoledronic acidzoledronic acid affects the expression of PPP2R2B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI17274953  19156129  21075311  25816751  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-IBA21873635  
GO:0006915apoptotic process-IEA-  
GO:0032502developmental process-IBA21873635  
GO:0043666regulation of phosphoprotein phosphatase activity-IEA-  
GO:0070262peptidyl-serine dephosphorylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000159protein phosphatase type 2A complex-IBA21873635  
GO:0005739mitochondrion-ISS-  
GO:0005741mitochondrial outer membrane-ISS-  
GO:0005829cytosol-IBA21873635  
GO:0005856cytoskeleton-IEA-  
KEGG ID KEGG Term
hsa03015mRNA surveillance pathway
hsa04530Tight junction
hsa05142Chagas disease (American trypanosomiasis)
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22797725Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. (2012 Jul 15)Dong JNat Genet