Gene: STEAP3

55240
AHMIO2|STMP3|TSAP6|dudlin-2|dudulin-2|pHyde
STEAP3 metalloreductase
protein-coding
2q14.2
Ensembl:ENSG00000115107 MIM:609671 Vega:OTTHUMG00000131402 UniprotKB:Q658P3
NG_042823.1
PubMed|SNP Mapped
2   ANCO-SNPs
CD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.803e-2 (AD)  3.394e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs72840936chr2:119266116 (GRCh38.p7)G>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs17805141chr2:119247993 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAB10.798
FCGBP0.78
CD330.764
MMP140.76
CCR50.756
SIGLEC90.755
CD300A0.752
RBM470.748
MS4A4A0.748
CIITA0.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.388
PPEF1-0.385
ADTRP-0.378
TPBGL-0.356
MYCNOS-0.355
SLC7A4-0.347
CYP4A11-0.347
DRD5-0.34
ATOH7-0.34
ABCC12-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STEAP3 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of STEAP3 mRNA]24530881
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of STEAP3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of STEAP3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of STEAP3 mRNA24449571
D001151ArsenicArsenic affects the methylation of STEAP3 gene25304211
C047723benzophenonebenzophenone results in decreased expression of STEAP3 mRNA22584684
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STEAP3 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STEAP3 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STEAP3 mRNA20106945|2623829
D004958EstradiolEstradiol results in increased expression of STEAP3 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STEAP3 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of STEAP3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of STEAP3 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of STEAP3 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of STEAP3 mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of STEAP3 promoter22457795
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in increased expression of STEAP3 protein]20359164
C018021cobaltous chloridecobaltous chloride results in decreased expression of STEAP3 mRNA19320972|1937684
D003300CopperSTEAP3 protein results in increased reduction of Copper16609065
D003300CopperSTEAP3 protein results in increased uptake of Copper16609065
D019327Copper SulfateCopper Sulfate results in decreased expression of STEAP3 mRNA19549813
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of STEAP3 protein23811945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STEAP3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of STEAP3 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of STEAP3 gene22964155
D003976DiazinonDiazinon affects the expression of STEAP3 mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of STEAP3 mRNA27392435
D004026DieldrinDieldrin affects the expression of STEAP3 mRNA22546817
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in increased expression of STEAP3 protein]20359164
D004041Dietary FatsDietary Fats results in increased expression of STEAP3 protein20359164
D002117CalcitriolCalcitriol results in increased expression of STEAP3 mRNA26485663
D004237DiuronDiuron results in decreased expression of STEAP3 mRNA25152437
C118739entinostatentinostat results in increased expression of STEAP3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of STEAP3 mRNA22584684
D005557FormaldehydeFormaldehyde results in decreased expression of STEAP3 mRNA23649840
D019833GenisteinGenistein results in increased expression of STEAP3 mRNA23019147
C010176halofuginonehalofuginone results in increased expression of STEAP3 mRNA17180598
D017313FenretinideFenretinide results in decreased expression of STEAP3 mRNA28973697
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of STEAP3 mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of STEAP3 mRNA24530881
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STEAP3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of STEAP3 mRNA28628672
D007501IronSTEAP3 protein affects the metabolism of Iron17194590
D007501IronSTEAP3 protein results in increased reduction of Iron16609065
D007501IronSTEAP3 protein results in increased uptake of Iron16609065
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STEAP3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of STEAP3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of STEAP3 mRNA27392435
C544151jinfukangjinfukang results in increased expression of STEAP3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STEAP3 mRNA26752646
C410337K 7174K 7174 results in decreased expression of STEAP3 mRNA24086573
D064704LevofloxacinLevofloxacin results in decreased expression of STEAP3 mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of STEAP3 mRNA25613284
C018091maduramicinmaduramicin results in increased expression of STEAP3 mRNA29128925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STEAP3 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of STEAP3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of STEAP3 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of STEAP3 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of STEAP3 mRNA24136188
C029938nickel sulfatenickel sulfate results in increased expression of STEAP3 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of STEAP3 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of STEAP3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of STEAP3 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of STEAP3 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of STEAP3 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of STEAP3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STEAP3 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of STEAP3 mRNA28903501
C513428pyrachlostrobinpyrachlostrobin results in increased expression of STEAP3 mRNA27029645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STEAP3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of STEAP3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STEAP3 mRNA28213091|2892240
D013853ThioacetamideThioacetamide results in decreased expression of STEAP3 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of STEAP3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of STEAP3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of STEAP3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of STEAP3 mRNA23724009|2383079
C012589trichostatin Atrichostatin A results in increased expression of STEAP3 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of STEAP3 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of STEAP3 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of STEAP3 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STEAP3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of STEAP3 mRNA24383497|2627250
D014638VanadatesVanadates results in increased expression of STEAP3 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22624035  
GO:0008823cupric reductase activity-IBA21873635  
GO:0016723oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor-TAS-  
GO:0046872metal ion binding-IEA-  
GO:0052851ferric-chelate reductase (NADPH) activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0009306protein secretion-IDA15319436  
GO:0009306protein secretion-IMP22624035  
GO:0015677copper ion import-IBA21873635  
GO:0033572transferrin transport-TAS-  
GO:0042981regulation of apoptotic process-TAS-  
GO:0055072iron ion homeostasis-IEA-  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO:0098706ferric iron import across plasma membrane-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA25468996  
GO:0005768endosome-IBA21873635  
GO:0005771multivesicular body-IDA15319436  
GO:0005886plasma membrane-IBA21873635  
GO:0010008endosome membrane-TAS-  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-917937Iron uptake and transportTAS
R-HSA-917977Transferrin endocytosis and recyclingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19334046Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. (2009 Jun)Boelens MCJ Pathol
26230583Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress. (2015)Slattery MLPLoS One
19603079Influence of smoking on colonic gene expression profile in Crohn's disease. (2009 Jul 15)Nielsen OHPLoS One