Gene: STK32B

55351
HSA250839|STK32|STKG6|YANK2
serine/threonine kinase 32B
protein-coding
4p16.2
Ensembl:ENSG00000152953 Vega:OTTHUMG00000090423 UniprotKB:Q9NY57
NG_051593.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.966e-1 (AD)  5.077e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6811343chr4:5080268 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA5A0.767
MEGF110.757
LHFPL30.728
BLM0.709
BEST30.706
STK32A0.698
HAS20.695
MATN20.687
PCOLCE20.686
TMEM255A0.677

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POU3F1-0.434
SCRT2-0.418
NOS2-0.405
PNLDC1-0.4
CCNO-0.395
KCNQ4-0.389
YBX2-0.385
ST6GALNAC5-0.383
CUX2-0.378
FGF9-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of STK32B mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of STK32B mRNA28959563
D001280AtrazineAtrazine results in increased expression of STK32B mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STK32B mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of STK32B mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of STK32B mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of STK32B promoter22457795
C018021cobaltous chloridecobaltous chloride results in decreased expression of STK32B mRNA19320972
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of STK32B mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of STK32B mRNA25016146
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of STK32B mRNA27392435
D052638Particulate MatterParticulate Matter results in increased expression of STK32B mRNA22178795
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of STK32B mRNA28511854
D011441PropylthiouracilPropylthiouracil results in increased expression of STK32B mRNA24780913
C017947sodium arsenitesodium arsenite affects the expression of STK32B mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK32B mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of STK32B gene26756918
D001335Vehicle EmissionsVehicle Emissions affects the methylation of STK32B gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of STK32B mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of STK32B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0035556intracellular signal transduction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal