Gene: SIRPG

55423
CD172g|SIRP-B2|SIRPB2|SIRPgamma|bA77C3.1
signal regulatory protein gamma
protein-coding
20p13
Ensembl:ENSG00000089012 MIM:605466 Vega:OTTHUMG00000031680 UniprotKB:Q9P1W8
NC_000020.11
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.755e-1 (AD)  3.755e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1535883chr20:1632173 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs3746722chr20:1630293 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBL4B0.646
PTGER10.563
PI150.562
LTB4R0.561
ALX30.555
MROH50.551
TFPI0.549
CD2470.548
GSDMA0.542
AADACL20.534

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOG-0.419
ABCD2-0.338
ERBB4-0.329
C1orf53-0.32
LRRN1-0.315
CYP7B1-0.315
ATP2C2-0.308
CHST9-0.307
WIF1-0.306
CA8-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SIRPG gene27153756
C018475butyraldehydebutyraldehyde results in decreased expression of SIRPG mRNA26079696
D005557FormaldehydeFormaldehyde results in decreased expression of SIRPG mRNA23649840
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SIRPG mRNA23086925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SIRPG mRNA23649840
D009532NickelNickel results in increased expression of SIRPG mRNA25583101
D014635Valproic AcidValproic Acid results in decreased methylation of SIRPG gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15383453  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007267cell-cell signaling-TAS9062191  
GO:0008284positive regulation of cell proliferation-IDA15383453  
GO:0008285negative regulation of cell proliferation-TAS9062191  
GO:0022409positive regulation of cell-cell adhesion-IBA21873635  
GO:0022409positive regulation of cell-cell adhesion-IDA15383453  
GO:0035556intracellular signal transduction-TAS9062191  
GO:0050766positive regulation of phagocytosis-IBA21873635  
GO:0050870positive regulation of T cell activation-IBA21873635  
GO:0050870positive regulation of T cell activation-IDA15383453  
GO:0050900leukocyte migration-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-IDA15383453  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-391160Signal regulatory protein family interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal