Gene: TTC27

55622
-
tetratricopeptide repeat domain 27
protein-coding
2p22.3
Ensembl:ENSG00000018699 Vega:OTTHUMG00000152134 UniprotKB:Q6P3X3
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.151e-1 (AD)  2.175e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6743661chr2:32708028 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TEFM0.762
PCNA0.762
INTS40.755
CNOT20.754
RARS20.75
NUP880.747
BUB30.747
C5orf150.744
N4BP2L20.743
EXOSC80.743

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.434
OR4F29-0.414
SEC14L3-0.279
HPSE2-0.241
WNT7B-0.239
HES5-0.234
DIO2-0.231
ZNF467-0.229
PYGM-0.213
EPPIN-0.202

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of TTC27 mRNA21420995|2906747
D020106AcrylamideAcrylamide results in increased expression of TTC27 mRNA28959563
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC27 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TTC27 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTC27 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TTC27 mRNA"20382639
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of TTC27 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of TTC27 mRNA21179406
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of TTC27 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of TTC27 mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TTC27 mRNA28472532
D016572CyclosporineCyclosporine results in increased expression of TTC27 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of TTC27 mRNA24317228
D002945CisplatinCisplatin results in decreased expression of TTC27 mRNA27594783
D004041Dietary FatsDietary Fats affects the expression of TTC27 mRNA19680557
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of TTC27 mRNA"21785161
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TTC27 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TTC27 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TTC27 mRNA23649840
D018120FinasterideFinasteride results in increased expression of TTC27 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of TTC27 mRNA24793618
D005485FlutamideFlutamide results in increased expression of TTC27 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TTC27 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TTC27 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TTC27 mRNA21889194|2343069
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TTC27 mRNA25982114
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TTC27 mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TTC27 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TTC27 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TTC27 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of TTC27 mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of TTC27 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TTC27 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TTC27 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of TTC27 mRNA21632981
C016104sodium bichromatesodium bichromate results in increased expression of TTC27 mRNA22155349
D012969Sodium FluorideSodium Fluoride results in increased expression of TTC27 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of TTC27 mRNA18175754
C013698tallowtallow affects the expression of TTC27 mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTC27 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTC27 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TTC27 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of TTC27 mRNA19464567
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TTC27 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of TTC27 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of TTC27 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TTC27 mRNA19042947
C406224valdecoxibvaldecoxib results in increased expression of TTC27 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of TTC27 mRNA23179753
D019287Zinc SulfateZinc Sulfate results in increased expression of TTC27 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal