Gene info: ID 55742

Gene: PARVA

GENE ID: 55742

Synonyms: CH-ILKBP|MXRA2

Description: parvin alpha

Gene type: protein-coding

Location: 11p15.3

dbXrefs: Ensembl:ENSG00000197702 MIM:608120 Vega:OTTHUMG00000165778 UniprotKB:Q9NVD7

RefSeq: NC_000011.10

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: OD|ND

# Publications: 1

Sherlock p-value : 3.965e-1 (AD) 4.445e-2 (ND) (Frontal_Cortex)

Pascal p-value : 1.148e-1 (AD) 2.993e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs73411566	chr11:12433197 (GRCh38.p7)	T>C	opioid dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg19360308	chr11:12423586	PARVA	Gene body	8.193e-5	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEBL	0.85
EIF4EBP2	0.842
CPE	0.834
DDAH1	0.825
AHCYL2	0.818
ABLIM1	0.813
GPD2	0.812
TMBIM6	0.812
PGM1	0.811
ASPH	0.806

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.651
OR4F29	-0.613
TNFRSF13B	-0.256
TRPV5	-0.247
TMEM139	-0.242
C10orf67	-0.226
OR6C74	-0.222
BTBD16	-0.217
KEL	-0.216
DYNAP	-0.207

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PARVA mRNA"	25510870
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PARVA mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PARVA mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PARVA mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PARVA mRNA"	25510870
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PARVA mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PARVA mRNA"	25510870
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PARVA protein	26194647
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARVA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PARVA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARVA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARVA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PARVA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARVA mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of PARVA mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PARVA mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of PARVA protein	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PARVA mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PARVA mRNA	19770486
D004958	Estradiol	Estradiol results in decreased expression of PARVA mRNA	19167446
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of PARVA mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of PARVA mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of PARVA mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of PARVA mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of PARVA mRNA	26191083
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PARVA mRNA	23650126
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PARVA mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of PARVA mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PARVA mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of PARVA mRNA	20187946
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PARVA mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PARVA mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of PARVA mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of PARVA mRNA	26577399
D002945	Cisplatin	Cisplatin results in increased expression of PARVA mRNA	21151649
D004041	Dietary Fats	Dietary Fats results in increased expression of PARVA mRNA	19030233\|2501614
D004237	Diuron	Diuron results in increased expression of PARVA mRNA	21551480
C118739	entinostat	entinostat results in decreased expression of PARVA mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARVA mRNA"	27188386
D005485	Flutamide	Flutamide results in decreased expression of PARVA mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PARVA mRNA	20938992
D019833	Genistein	Genistein results in decreased expression of PARVA mRNA	22228119
D017313	Fenretinide	Fenretinide results in decreased expression of PARVA mRNA	28973697
C492448	ICG 001	ICG 001 results in increased expression of PARVA mRNA	26191083
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PARVA mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PARVA mRNA	28001369
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of PARVA protein"	21135415
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of PARVA mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PARVA mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of PARVA mRNA	25583101
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of PARVA mRNA	25729387
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PARVA mRNA"	25510870
D010656	Phenylephrine	Phenylephrine affects the localization of PARVA protein	16170337
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PARVA mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PARVA mRNA	26272509
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of PARVA mRNA	23608068
D011374	Progesterone	Progesterone results in decreased expression of PARVA mRNA	23018184
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of PARVA mRNA	27029645
C017947	sodium arsenite	sodium arsenite results in increased stability of PARVA mRNA	25493608
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of PARVA mRNA	27862939
D013739	Testosterone	Testosterone results in decreased expression of PARVA mRNA	21669218
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PARVA mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PARVA mRNA	18796159
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of PARVA mRNA	28111298
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of PARVA mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of PARVA mRNA	23724009
C057693	troglitazone	troglitazone results in decreased expression of PARVA mRNA	28973697
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PARVA mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PARVA mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of PARVA mRNA	24935251\|2627250
C025643	vinclozolin	vinclozolin affects the expression of PARVA mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of PARVA mRNA	23034163
D014810	Vitamin E	Vitamin E results in decreased expression of PARVA mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003779	actin binding	-	IBA	21873635
GO:0003779	actin binding	-	IEA	-
GO:0005515	protein binding	-	IPI	12432066 16189514 17353931 17553790 21516116 23455922 23877428 25416956 25852190 26496610
GO:0045296	cadherin binding	-	HDA	25468996

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002040	sprouting angiogenesis	-	ISS	-
GO:0003148	outflow tract septum morphogenesis	-	ISS	-
GO:0007163	establishment or maintenance of cell polarity	-	IBA	21873635
GO:0007163	establishment or maintenance of cell polarity	-	ISS	-
GO:0008360	regulation of cell shape	-	IEA	-
GO:0030031	cell projection assembly	-	IBA	21873635
GO:0031532	actin cytoskeleton reorganization	-	IBA	21873635
GO:0031532	actin cytoskeleton reorganization	-	IEA	-
GO:0034113	heterotypic cell-cell adhesion	-	ISS	-
GO:0034446	substrate adhesion-dependent cell spreading	-	IBA	21873635
GO:0034446	substrate adhesion-dependent cell spreading	-	IMP	11331308
GO:0060271	cilium assembly	-	IBA	21873635
GO:0060271	cilium assembly	-	IMP	20393563
GO:0070252	actin-mediated cell contraction	-	ISS	-
GO:0071670	smooth muscle cell chemotaxis	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	IEA	-
GO:0005886	plasma membrane	-	IEA	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0005925	focal adhesion	-	IBA	21873635
GO:0005925	focal adhesion	-	IDA	11331308
GO:0015629	actin cytoskeleton	-	IBA	21873635
GO:0030018	Z disc	-	IEA	-

KEGG ID	KEGG Term
hsa04510	Focal adhesion

Reactome ID	Reactome Term	Evidence
R-HSA-1500931	Cell-Cell communication	TAS
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	TAS
R-HSA-446353	Cell-extracellular matrix interactions	TAS
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	TAS
R-HSA-446728	Cell junction organization	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25517428	Smoking-Associated Site-Specific Differential Methylation in Buccal Mucosa in the COPDGene Study. (2015 Aug)	Wan ES	Am J Respir Cell Mol Biol