Gene: ZNF415

55786
Pact|ZfLp
zinc finger protein 415
protein-coding
19q13.42
Ensembl:ENSG00000170954 Vega:OTTHUMG00000182865 UniprotKB:Q09FC8
NC_000019.10
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.481e-1 (AD)  4.322e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10423632chr19:53130297 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC35A50.872
ZNF3020.872
FAM69A0.869
SEC22C0.867
TRIM20.864
UBA30.856
STX70.855
ZRANB20.855
CLASP20.855
TERF10.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.572
C8orf74-0.358
TFPI2-0.326
MTRNR2L10-0.325
MTRNR2L6-0.323
MTRNR2L3-0.32
KLRB1-0.306
KCNJ15-0.305
TRIM10-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF415 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF415 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ZNF415 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ZNF415 protein20106945
D001280AtrazineAtrazine results in decreased expression of ZNF415 mRNA22378314
D016572CyclosporineCyclosporine results in increased expression of ZNF415 mRNA20106945
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of ZNF415 mRNA]21095227
C045463leflunomideleflunomide results in increased expression of ZNF415 mRNA28988120
D009532NickelNickel results in decreased expression of ZNF415 mRNA24768652|2558310
D010100OxygenOxygen deficiency results in decreased expression of ZNF415 mRNA24236059
D010100OxygenOxygen deficiency results in increased expression of ZNF415 mRNA26516004
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of ZNF415 mRNA]21095227
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF415 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ZNF415 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased expression of ZNF415 mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0015630microtubule cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25129674Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)McClintick JNAlcohol