Gene: PLGRKT

55848
AD025|C9orf46|MDS030|PLG-RKT|Plg-R(KT)
plasminogen receptor with a C-terminal lysine
protein-coding
9p24.1
Ensembl:ENSG00000107020 Vega:OTTHUMG00000019501 UniprotKB:Q9HBL7
NC_000009.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.033e-1 (AD)  6.703e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3824435chr9:5377115 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PEX20.819
LYPLAL10.789
TMCO10.783
TMBIM40.775
C2orf760.773
ETFA0.766
POLR2G0.765
SNX50.762
TMEM2180.759
DARS0.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.478
OR4F29-0.436
TTLL2-0.316
OPRD1-0.314
KLHL38-0.293
CYP27C1-0.284
PROKR2-0.279
KLHL34-0.278
TUBA8-0.269
METTL21C-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of PLGRKT mRNA22230336
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PLGRKT mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLGRKT mRNA26238291
D004958EstradiolEstradiol results in decreased expression of PLGRKT mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PLGRKT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PLGRKT gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PLGRKT mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PLGRKT mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLGRKT mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PLGRKT mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PLGRKT mRNA25562108
C000944dicrotophosdicrotophos results in decreased expression of PLGRKT mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLGRKT mRNA22079256
C039281furanfuran results in increased expression of PLGRKT mRNA25539665
C016517indole-3-carbinolindole-3-carbinol affects the expression of PLGRKT mRNA21396975
D007213IndomethacinIndomethacin results in decreased expression of PLGRKT mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLGRKT mRNA25613284
D007649KetamineKetamine results in decreased expression of PLGRKT mRNA20080153
D007854LeadLead affects the splicing of PLGRKT mRNA28903495
D064704LevofloxacinLevofloxacin results in decreased expression of PLGRKT mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLGRKT mRNA27339419
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PLGRKT mRNA23649840
D010416PentachlorophenolPentachlorophenol results in increased expression of PLGRKT mRNA23892564
D010936Plant ExtractsPlant Extracts results in increased expression of PLGRKT mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLGRKT mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PLGRKT mRNA22079256
C012526quercitrinquercitrin results in decreased expression of PLGRKT mRNA25193878
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLGRKT mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLGRKT mRNA25613284
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PLGRKT mRNA29024780
D014520UrethaneUrethane results in decreased expression of PLGRKT mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PLGRKT mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PLGRKT gene25560391
C111237vorinostatvorinostat results in increased expression of PLGRKT mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0010756positive regulation of plasminogen activation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28990359Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. (2017 Dec)Polimanti RAm J Med Genet B Neuropsychiatr Genet