Gene: PROS1

5627
PROS|PS21|PS22|PS23|PS24|PS25|PSA|THPH5|THPH6
protein S
protein-coding
3q11.1
Ensembl:ENSG00000184500 MIM:176880 Vega:OTTHUMG00000150354 UniprotKB:P07225
NG_009813.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.556e-1 (AD)  1.664e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7428007chr3:93919173 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CMTM60.856
CFI0.849
KDELC20.846
IL13RA10.845
MAP3K80.843
SLC26A20.836
RNF144B0.834
ABCC40.831
IFNAR20.827
TMOD30.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.465
MAGIX-0.445
KCNIP3-0.444
BCL11A-0.434
RTN4R-0.43
WNT7A-0.421
TMEM179-0.414
EXTL1-0.41
C19orf73-0.41
MYADML2-0.404

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00055Drotrecogin alfaBiotechDrug98530-76-8Approved|Investigational|WithdrawnTarget
DB00170MenadioneSmall Molecule58-27-5Approved|NutraceuticalTarget
DB00464Sodium Tetradecyl SulfateSmall Molecule139-88-8Approved|InvestigationalTarget
DB09332KappadioneSmall Molecule131-13-5ApprovedTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PROS1 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of PROS1 mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PROS1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PROS1 mRNA"21346803
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased expression of PROS1 mRNA"20926118
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PROS1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PROS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PROS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROS1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PROS1 mRNA22230336|2776149
C430898AGN 194204AGN 194204 results in increased expression of PROS1 mRNA16339527
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PROS1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PROS1 mRNA16483693
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of PROS1 mRNA"22352330
D001205Ascorbic AcidAscorbic Acid results in decreased expression of PROS1 mRNA15372504
D001280AtrazineAtrazine results in increased expression of PROS1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PROS1 mRNA22228805|2261060
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PROS1 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PROS1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of PROS1 protein12730085
D004958EstradiolEstradiol results in increased expression of PROS1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of PROS1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of PROS1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PROS1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PROS1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of PROS1 mRNA18958704
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PROS1 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of PROS1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PROS1 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PROS1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PROS1 mRNA16239168
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of PROS1 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of PROS1 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of PROS1 mRNA27344345
D002994ClofibrateClofibrate results in decreased expression of PROS1 mRNA17585979
C044626CMF protocolCMF protocol results in decreased expression of PROS1 protein8879681
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of PROS1 mRNA20105288
D003276Contraceptives, Oral"Contraceptives, Oral results in decreased activity of PROS1 protein"8598720
D003276Contraceptives, Oral"Contraceptives, Oral results in decreased expression of PROS1"15185533
D019327Copper SulfateCopper Sulfate results in decreased expression of PROS1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PROS1 mRNA27523638
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of PROS1 mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of PROS1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of PROS1 mRNA19770486
C014347decitabinedecitabine affects the expression of PROS1 mRNA23300844
D017135DesogestrelDesogestrel affects the expression of PROS1 protein11442481
D002945CisplatinCisplatin affects the expression of PROS1 mRNA23300844
D002945CisplatinPROS1 protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in increased expression of PROS1 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of PROS1 mRNA28302478
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 protein15288212
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of PROS1 mRNA21852083
D004128DimethylnitrosamineDimethylnitrosamine affects the expression of PROS1 mRNA16995903
D004128DimethylnitrosamineDimethylnitrosamine affects the expression of PROS1 protein16995903
D004237DiuronDiuron results in decreased expression of PROS1 mRNA25152437
D004298DopamineDopamine results in increased expression of PROS1 mRNA21983523
C118739entinostatentinostat results in decreased expression of PROS1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PROS1 mRNA"27188386
C454300estradiol valerate-dienogest[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of PROS1 protein15288212
D004967EstrogensEstrogens results in decreased expression of PROS111461176
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) results in decreased expression of PROS1 protein"15850603
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of PROS1 mRNA27344345
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PROS1 protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of PROS1 protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROS1 protein11720199
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of PROS1 protein11994571
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PROS1 protein12618251|1652252
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROS115669648
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of PROS1 protein14551147
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of PROS1 protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of PROS1 protein12618251
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PROS1 protein17374706|8950781
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in decreased activity of PROS1 protein11994571|1455114
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in decreased expression of PROS1 protein10928463|1261825
C072593ethinyl estradiol, levonorgestrel drug combination"ethinyl estradiol, levonorgestrel drug combination results in decreased expression of PROS1 protein"18238963
D018818FenoldopamFenoldopam results in increased expression of PROS1 mRNA21983523
C082360fipronilfipronil results in increased expression of PROS1 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of PROS1 mRNA24136188
D019833GenisteinGenistein results in decreased expression of PROS1 mRNA20926118
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROS1 protein11720199
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of PROS1 protein11994571
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PROS1 protein12618251|1652252
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROS115669648
C033273GestodeneGestodene results in decreased expression of PROS1 protein12730085
D005897GlafenineGlafenine results in decreased expression of PROS1 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PROS1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PROS1 mRNA27339419
D008727MethotrexateMethotrexate results in increased expression of PROS1 mRNA17400583
C005219methyl cellosolvemethyl cellosolve results in increased expression of PROS1 mRNA21061450
C523799MRK 003PROS1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PROS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PROS1 mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of PROS1 mRNA27344345
D009532NickelPROS1 protein binds to Nickel23896426
C029938nickel sulfatenickel sulfate results in decreased expression of PROS1 mRNA22714537
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of PROS1 protein12618251
C109079norgestimate, ethinyl estradiol drug combination"norgestimate, ethinyl estradiol drug combination results in decreased expression of PROS1 protein"8950781
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of PROS1 protein14551147
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of PROS1 protein12618251
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PROS1 mRNA25729387
C016030pantogabpantogab results in increased expression of PROS1 mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of PROS1 mRNA17987463
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of PROS1 mRNA19095052
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of PROS1 mRNA28973697
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PROS1 protein26879310
D010578PetroleumPetroleum affects the expression of PROS1 mRNA25208076
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of PROS1 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of PROS1 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROS1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PROS1 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of PROS1 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PROS1 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PROS1 mRNA21334430
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PROS1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PROS1 mRNA28903501
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PROS1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of PROS1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PROS1 protein15850603
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of PROS1 protein16202731
C059514resveratrolresveratrol results in decreased expression of PROS1 mRNA20926118
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of PROS1 mRNA21852083
D015474IsotretinoinIsotretinoin results in increased expression of PROS1 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PROS1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PROS1 mRNA19073995
D012999SomanSoman results in increased expression of PROS1 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of PROS1 protein15850603
D013629TamoxifenTamoxifen results in decreased expression of PROS1 protein12492585
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of PROS1 mRNA20189893
C004648testosterone enanthatetestosterone enanthate results in decreased expression of PROS1 protein8585008
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PROS1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PROS1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PROS1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of PROS1 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PROS1 mRNA18796159|2629044
D019284ThapsigarginThapsigargin results in decreased expression of PROS1 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PROS1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PROS1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of PROS1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of PROS1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of PROS1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PROS1 mRNA"26179874
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of PROS1 mRNA20105288
C002802tungsten carbidetungsten carbide results in decreased expression of PROS1 mRNA20105288
D014415TunicamycinTunicamycin results in decreased expression of PROS1 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROS1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PROS1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of PROS1 mRNA23179753|2438349
D014640VancomycinVancomycin results in decreased expression of PROS1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PROS1 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PROS1 gene25560391
D014812Vitamin KVitamin K affects the carboxylation of and affects the secretion of PROS1 protein10706868
D010837Vitamin K 1Vitamin K 1 results in increased secretion of PROS1 protein22290807
D014859WarfarinPROS1 gene polymorphism affects the susceptibility to Warfarin19752777
D014859WarfarinPROS1 protein affects the susceptibility to Warfarin19752777
D014859WarfarinPROS1 protein results in decreased susceptibility to Warfarin22290807
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of PROS1 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS8146182  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007596blood coagulation-TAS-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO:0042730fibrinolysis-IEA-  
GO:0050900leukocyte migration-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA14607961  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-159740Gamma-carboxylation of protein precursorsTAS
R-HSA-159763Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusTAS
R-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteinsTAS
R-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal