Gene: ASAH2

56624
BCDase|HNAC1|LCDase|N-CDase|NCDase
N-acylsphingosine amidohydrolase 2
protein-coding
10q11.23
Ensembl:ENSG00000188611 MIM:611202 Vega:OTTHUMG00000018223 UniprotKB:Q9NR71
NC_000010.11
SNP Mapped
OD
0   
2.741e-1 (AD)  8.598e-1 (ND)   (Frontal_Cortex)
2.588e-1 (AD)  6.095e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1898198chr10:50249888 (GRCh38.p7)A>Gopioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBTPS20.631
TASP10.624
ZNF7200.617
MAP100.617
TUBGCP50.614
BBS70.606
RINT10.604
PCSK10.598
SLC4A80.597
FAR20.595

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.398
CCDC102A-0.397
RHOD-0.392
EVC2-0.384
ACOX2-0.373
TCF7L1-0.372
AKR1C3-0.369
SIX5-0.366
CASP7-0.365
SMO-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ASAH2 mRNA"25614096
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ASAH2 mRNA"21346803
C0293704-toluidine4-toluidine results in increased expression of ASAH2 mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of ASAH2 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ASAH2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ASAH2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ASAH2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ASAH2 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of ASAH2 mRNA25258189
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ASAH2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ASAH2 mRNA19770486
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ASAH2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ASAH2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ASAH2 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ASAH2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of ASAH2 protein18226198
D002251Carbon TetrachlorideFlavonoids inhibits the reaction [Carbon Tetrachloride results in decreased activity of ASAH2 protein]18226198
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASAH2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ASAH2 mRNA28472532
D003300CopperCopper deficiency results in decreased expression of ASAH2 mRNA19821111
D003300CopperCopper deficiency results in increased expression of ASAH2 mRNA26033743
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ASAH2 mRNA23640034
D003907DexamethasoneDexamethasone results in decreased expression of ASAH2 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ASAH2 mRNA]20032058
D002945CisplatinCisplatin results in increased expression of ASAH2 mRNA21151649
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ASAH2 mRNA26924002
D019422Dietary SucroseDietary Sucrose results in increased expression of ASAH2 mRNA26033743
C024629dimethyl phthalatedimethyl phthalate affects the expression of ASAH2 mRNA26924002
D004147DioxinsDioxins affects the expression of ASAH2 mRNA20463971
D005419FlavonoidsFlavonoids inhibits the reaction [Carbon Tetrachloride results in decreased activity of ASAH2 protein]18226198
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASAH2 mRNA20938992
C039281furanfuran results in increased expression of ASAH2 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of ASAH2 mRNA28973697
C045463leflunomideleflunomide results in increased expression of ASAH2 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASAH2 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ASAH2 mRNA"26251327
C059539midostaurinmidostaurin results in decreased expression of ASAH2 mRNA20980353
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ASAH2 mRNA26924002
C061800N,N-dimethylsphingosine"N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein]"15498114
C097760N-palmitoylsphingosineASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]15946935
C006253pirinixic acidpirinixic acid results in decreased expression of ASAH2 mRNA17426115
D011441PropylthiouracilPropylthiouracil results in decreased expression of ASAH2 mRNA24780913
D012402RotenoneRotenone results in increased expression of ASAH2 mRNA23186747
C016104sodium bichromatesodium bichromate results in decreased expression of ASAH2 mRNA22561333
D018038Sodium SeleniteSodium Selenite results in increased expression of ASAH2 mRNA24383545
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ASAH2 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASAH2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ASAH2 mRNA19465110
D013853ThioacetamideThioacetamide results in increased expression of ASAH2 mRNA23411599
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ASAH2 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ASAH2 mRNA29024780
D014635Valproic AcidValproic Acid results in decreased methylation of ASAH2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ASAH2 gene25560391
D015032ZincZinc deficiency results in increased expression of ASAH2 mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IDA26190575  
GO:0008270zinc ion binding-IDA26190575  
GO:0017040N-acylsphingosine amidohydrolase activity-IBA21873635  
GO:0017040N-acylsphingosine amidohydrolase activity-IDA26190575  
GO:0102121ceramidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006670sphingosine metabolic process-IDA26190575  
GO:0006672ceramide metabolic process-IDA26190575  
GO:0006915apoptotic process-IEA-  
GO:0042759long-chain fatty acid biosynthetic process-IBA21873635  
GO:0046512sphingosine biosynthetic process-IBA21873635  
GO:0046514ceramide catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005739mitochondrion-TAS10781606  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal