Gene info: ID 56624

Gene: ASAH2

GENE ID: 56624

Synonyms: BCDase|HNAC1|LCDase|N-CDase|NCDase

Description: N-acylsphingosine amidohydrolase 2

Gene type: protein-coding

Location: 10q11.23

dbXrefs: Ensembl:ENSG00000188611 MIM:611202 Vega:OTTHUMG00000018223 UniprotKB:Q9NR71

RefSeq: NC_000010.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: OD

# Publications: 0

Sherlock p-value : 2.741e-1 (AD) 8.598e-1 (ND) (Frontal_Cortex)

Pascal p-value : 2.588e-1 (AD) 6.095e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1898198	chr10:50249888 (GRCh38.p7)	A>G	opioid dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MBTPS2	0.631
TASP1	0.624
ZNF720	0.617
MAP10	0.617
TUBGCP5	0.614
BBS7	0.606
RINT1	0.604
PCSK1	0.598
SLC4A8	0.597
FAR2	0.595

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EYA2	-0.398
CCDC102A	-0.397
RHOD	-0.392
EVC2	-0.384
ACOX2	-0.373
TCF7L1	-0.372
AKR1C3	-0.369
SIX5	-0.366
CASP7	-0.365
SMO	-0.363

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ASAH2 mRNA"	25614096
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ASAH2 mRNA"	21346803
C029370	4-toluidine	4-toluidine results in increased expression of ASAH2 mRNA	27638505
D000082	Acetaminophen	Acetaminophen affects the expression of ASAH2 mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of ASAH2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ASAH2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ASAH2 mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ASAH2 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ASAH2 mRNA	25258189
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of ASAH2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ASAH2 mRNA	19770486
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of ASAH2 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of ASAH2 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of ASAH2 mRNA	25181051
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ASAH2 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased activity of ASAH2 protein	18226198
D002251	Carbon Tetrachloride	Flavonoids inhibits the reaction [Carbon Tetrachloride results in decreased activity of ASAH2 protein]	18226198
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASAH2 mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of ASAH2 mRNA	28472532
D003300	Copper	Copper deficiency results in decreased expression of ASAH2 mRNA	19821111
D003300	Copper	Copper deficiency results in increased expression of ASAH2 mRNA	26033743
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of ASAH2 mRNA	23640034
D003907	Dexamethasone	Dexamethasone results in decreased expression of ASAH2 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of ASAH2 mRNA]	20032058
D002945	Cisplatin	Cisplatin results in increased expression of ASAH2 mRNA	21151649
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ASAH2 mRNA	26924002
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of ASAH2 mRNA	26033743
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of ASAH2 mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of ASAH2 mRNA	20463971
D005419	Flavonoids	Flavonoids inhibits the reaction [Carbon Tetrachloride results in decreased activity of ASAH2 protein]	18226198
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASAH2 mRNA	20938992
C039281	furan	furan results in increased expression of ASAH2 mRNA	25539665
D017313	Fenretinide	Fenretinide results in decreased expression of ASAH2 mRNA	28973697
C045463	leflunomide	leflunomide results in increased expression of ASAH2 mRNA	28988120
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASAH2 mRNA	20938992
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ASAH2 mRNA"	26251327
C059539	midostaurin	midostaurin results in decreased expression of ASAH2 mRNA	20980353
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ASAH2 mRNA	26924002
C061800	N,N-dimethylsphingosine	"N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein]"	15498114
C097760	N-palmitoylsphingosine	ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]	15946935
C006253	pirinixic acid	pirinixic acid results in decreased expression of ASAH2 mRNA	17426115
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ASAH2 mRNA	24780913
D012402	Rotenone	Rotenone results in increased expression of ASAH2 mRNA	23186747
C016104	sodium bichromate	sodium bichromate results in decreased expression of ASAH2 mRNA	22561333
D018038	Sodium Selenite	Sodium Selenite results in increased expression of ASAH2 mRNA	24383545
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of ASAH2 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ASAH2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ASAH2 mRNA	19465110
D013853	Thioacetamide	Thioacetamide results in increased expression of ASAH2 mRNA	23411599
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of ASAH2 mRNA	19042947
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ASAH2 mRNA	29024780
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ASAH2 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of ASAH2 gene	25560391
D015032	Zinc	Zinc deficiency results in increased expression of ASAH2 mRNA	19111725

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	IDA	26190575
GO:0008270	zinc ion binding	-	IDA	26190575
GO:0017040	N-acylsphingosine amidohydrolase activity	-	IBA	21873635
GO:0017040	N-acylsphingosine amidohydrolase activity	-	IDA	26190575
GO:0102121	ceramidase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006670	sphingosine metabolic process	-	IDA	26190575
GO:0006672	ceramide metabolic process	-	IDA	26190575
GO:0006915	apoptotic process	-	IEA	-
GO:0042759	long-chain fatty acid biosynthetic process	-	IBA	21873635
GO:0046512	sphingosine biosynthetic process	-	IBA	21873635
GO:0046514	ceramide catabolic process	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IBA	21873635
GO:0005739	mitochondrion	-	TAS	10781606
GO:0005886	plasma membrane	-	IEA	-
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00600	Sphingolipid metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1660662	Glycosphingolipid metabolism	TAS
R-HSA-428157	Sphingolipid metabolism	TAS
R-HSA-556833	Metabolism of lipids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal