Gene: KCNK13

56659
K2p13.1|THIK-1|THIK1
potassium two pore domain channel subfamily K member 13
protein-coding
14q32.11
Ensembl:ENSG00000152315 MIM:607367 Vega:OTTHUMG00000171017 UniprotKB:Q9HB14
NC_000014.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.233e-1 (AD)  9.272e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7149330chr14:90169862 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT5A0.717
PIK3CG0.693
RGS190.69
SLA0.673
CTSC0.666
TGFBI0.664
CCR50.656
CCR10.655
PIK3AP10.652
GPR1600.647

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX22-0.39
HPDL-0.348
MOBP-0.343
HHATL-0.338
SOX3-0.336
CA14-0.326
NEU4-0.325
MBP-0.317
PAQR6-0.315
OLIG1-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of KCNK13 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of KCNK13 mRNA29067470
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of KCNK13 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNK13 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCNK13 mRNA20064835
C006780bisphenol Abisphenol A affects the expression of KCNK13 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNK13 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of KCNK1320938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCNK13 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNK13 mRNA20938992
D016572CyclosporineCyclosporine results in decreased expression of KCNK13 mRNA25596134
D004237DiuronDiuron results in increased expression of KCNK13 mRNA21551480
D011345FenofibrateFenofibrate results in increased expression of KCNK13 mRNA25572481|2559613
D005419FlavonoidsFlavonoids results in increased expression of KCNK13 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of KCNK1320938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCNK13 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNK13 mRNA20938992
D017313FenretinideFenretinide results in decreased expression of KCNK13 mRNA28973697
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of KCNK13 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of KCNK1320938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCNK13 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KCNK13 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KCNK13 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KCNK13 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KCNK13 mRNA"25554681
D011441PropylthiouracilPropylthiouracil results in increased expression of KCNK13 mRNA24780913
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of KCNK13 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of KCNK13 gene26431795
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KCNK13 mRNA"26179874
D014520UrethaneUrethane results in increased expression of KCNK13 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KCNK13 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005267potassium channel activity-TAS-  
GO:0022841potassium ion leak channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0030322stabilization of membrane potential-IBA21873635  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296346Tandem pore domain potassium channelsTAS
R-HSA-1299287Tandem pore domain halothane-inhibited K+ channel (THIK)TAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576886Phase 4 - resting membrane potentialTAS
R-HSA-5576891Cardiac conductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal