Gene: CELF4

56853
BRUNOL4|CELF-4
CUGBP Elav-like family member 4
protein-coding
18q12.2
Ensembl:ENSG00000101489 MIM:612679 Vega:OTTHUMG00000178178 UniprotKB:Q9BZC1
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.883e-1 (AD)  7.146e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10502674chr18:37507420 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYN20.965
SNAP910.954
ATCAY0.954
SCAMP50.953
DNM10.952
STXBP10.951
SULT4A10.95
ARHGAP440.949
SYT10.949
ATP1A30.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.552
OR4F29-0.517
REST-0.5
TFPI2-0.492
RAI14-0.49
WWTR1-0.471
FZD10-0.465
IL2RG-0.463
RUNX3-0.463
ASB4-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0386251-N-methyl-5-thiotetrazole1-N-methyl-5-thiotetrazole results in increased expression of CELF4 mRNA28465218
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CELF4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CELF4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CELF4 mRNA22230336|2669055
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CELF4 gene27153756
D000447AldehydesAldehydes results in increased expression of CELF4 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CELF4 mRNA24449571
D001151ArsenicArsenic affects the methylation of CELF4 gene25304211
C015001arsenitearsenite results in increased methylation of CELF4 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CELF4 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CELF4 mRNA21839799
D004958EstradiolEstradiol results in increased expression of CELF4 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of CELF4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CELF4 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of CELF4 mRNA26079696
D002438CefoperazoneCefoperazone metabolite results in decreased expression of CELF4 mRNA28465218
D002438CefoperazoneCefoperazone results in decreased expression of CELF4 mRNA28465218
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CELF4 gene20938992
C014347decitabinedecitabine results in decreased methylation of CELF4 gene27923600
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CELF4 mRNA]27941970
D004041Dietary FatsDietary Fats results in decreased expression of CELF4 mRNA25016146
C118739entinostatentinostat results in decreased expression of CELF4 mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CELF4 gene20938992
D017313FenretinideFenretinide results in increased expression of CELF4 mRNA28973697
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CELF4 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CELF4 mRNA23179753
C523799MRK 003CELF4 results in decreased susceptibility to MRK 00319903844
C028007nickel monoxidenickel monoxide results in decreased expression of CELF4 mRNA19167457
C046012pentanalpentanal results in increased expression of CELF4 mRNA26079696
C005556propionaldehydepropionaldehyde results in increased expression of CELF4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CELF4 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of CELF4 mRNA27862939
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CELF4 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CELF4 promoter]19654925
D014212TretinoinTretinoin results in decreased expression of CELF4 mRNA16604517
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CELF4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CELF4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CELF4 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of CELF4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CELF4 gene25560391
C025643vinclozolinvinclozolin affects the expression of CELF4 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of CELF4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000900translation repressor activity, mRNA regulatory element binding-NAS10893231  
GO:0003723RNA binding-IBA21873635  
GO:0003729mRNA binding-IBA21873635  
GO:0003729mRNA binding-IEA-  
GO:0036002pre-mRNA binding-IDA11158314  
GO:0042835BRE binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000380alternative mRNA splicing, via spliceosome-IDA19720736  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IDA11158314  19720736  
GO:0006376mRNA splice site selection-IBA21873635  
GO:0006376mRNA splice site selection-IEA-  
GO:0007281germ cell development-NAS10893231  
GO:0009792embryo development ending in birth or egg hatching-NAS10893231  
GO:0017148negative regulation of translation-IEA-  
GO:0048025negative regulation of mRNA splicing, via spliceosome-IEA-  
GO:0048026positive regulation of mRNA splicing, via spliceosome-IDA15009664  
GO:0090394negative regulation of excitatory postsynaptic potential-IEA-  
GO:1902866regulation of retina development in camera-type eye-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11158314  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal