Gene: AGPAT4

56895
1-AGPAT4|LPAAT-delta|dJ473J16.2
1-acylglycerol-3-phosphate O-acyltransferase 4
protein-coding
6q26
Ensembl:ENSG00000026652 MIM:614795 Vega:OTTHUMG00000015966 UniprotKB:Q9NRZ5
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.979e-1 (AD)  8.038e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12191615chr6:161144126 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07074571chr6:161695561AGPAT41.600e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFASC0.919
CEP850.911
NACAD0.902
SEC14L50.899
DSCAML10.887
ANAPC50.887
HID10.883
TTLL70.88
LRRC8D0.877
UNC5C0.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJB2-0.42
OR4F5-0.419
ZIC5-0.402
OR4F29-0.401
ARHGAP42-0.38
MTRNR2L10-0.379
MTRNR2L6-0.378
LRAT-0.376
ASB4-0.374
EVC2-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AGPAT4 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of AGPAT4 mRNA"20005886
D000082AcetaminophenAcetaminophen affects the expression of AGPAT4 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of AGPAT4 mRNA17562736
C068073Am 580Am 580 results in increased expression of AGPAT4 mRNA16982809
D000638AmiodaroneAmiodarone affects the expression of AGPAT4 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AGPAT4 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of AGPAT4 mRNA21461292
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGPAT4 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGPAT4 mRNA"20382639
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of AGPAT4 mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of AGPAT4 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of AGPAT4 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of AGPAT4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of AGPAT4 mRNA25181051
D002746ChlorpromazineChlorpromazine affects the expression of AGPAT4 mRNA25064622
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AGPAT4 mRNA20938992
D019327Copper SulfateCopper Sulfate results in increased expression of AGPAT4 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of AGPAT4 mRNA27523638
D016572CyclosporineCyclosporine affects the expression of AGPAT4 mRNA25064622
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of AGPAT4 mRNA24317228
D003907DexamethasoneDexamethasone results in decreased expression of AGPAT4 mRNA25047013
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AGPAT4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of AGPAT4 mRNA22023808
D000431EthanolEthanol results in increased expression of AGPAT4 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AGPAT4 mRNA25064622
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGPAT4 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AGPAT4 mRNA20938992
C039281furanfuran results in increased expression of AGPAT4 mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of AGPAT4 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of AGPAT4 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGPAT4 mRNA25613284
C051890irinotecanirinotecan affects the expression of AGPAT4 mRNA20097248
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AGPAT4 mRNA27392435
D008627Mercuric ChlorideMercuric Chloride affects the expression of AGPAT4 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AGPAT4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AGPAT4 mRNA28001369
C523799MRK 003AGPAT4 results in increased susceptibility to MRK 00319903844
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of AGPAT4 mRNA17616710
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of AGPAT4 mRNA25729387
D010269ParaquatParaquat affects the expression of AGPAT4 mRNA25064622
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AGPAT4 mRNA22714537
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of AGPAT4 mRNA17404688
C059514resveratrolresveratrol results in increased expression of AGPAT4 protein25505154
C089730rosiglitazonerosiglitazone results in increased expression of AGPAT4 mRNA16982809
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AGPAT4 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of AGPAT4 gene28589171
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGPAT4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AGPAT4 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AGPAT4 mRNA28238261
D013752TetracyclineTetracycline affects the expression of AGPAT4 mRNA25064622
D013752TetracyclineTetracycline results in decreased expression of AGPAT4 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGPAT4 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of AGPAT4 mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AGPAT4 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of AGPAT4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of AGPAT4 mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of AGPAT4 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of AGPAT4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AGPAT4 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of AGPAT4 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AGPAT4 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of AGPAT4 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-IBA21873635  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-NAS15367102  
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0016746transferase activity, transferring acyl groups-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-IBA21873635  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0008654phospholipid biosynthetic process-NAS15367102  
GO:0016024CDP-diacylglycerol biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0012505endomembrane system-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal