Gene: ANKS1B

56899
AIDA|AIDA-1|ANKS2|EB-1|EB1|cajalin-2
ankyrin repeat and sterile alpha motif domain containing 1B
protein-coding
12q23.1
Ensembl:ENSG00000185046 MIM:607815 Vega:OTTHUMG00000170308 UniprotKB:Q7Z6G8
NG_029860.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.734e-1 (AD)  5.131e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10735366chr12:99372428 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs11109794chr12:99283218 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17367186chr12:99126816 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2372644chr12:99096982 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKACB0.94
PPP1R9A0.936
TRIM230.935
NALCN0.933
DNAJC60.931
AK50.929
TMEM1810.928
UBR30.927
SRPK20.927
CUL20.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.521
OR4F5-0.476
RUNX3-0.472
RNF135-0.469
EVC2-0.461
PDZK1IP1-0.457
OR4F29-0.451
MAGEA12-0.445
RHOD-0.439
FZD10-0.435

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANKS1B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANKS1B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANKS1B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANKS1B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANKS1B mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKS1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKS1B mRNA"27188386
D001151ArsenicArsenic affects the methylation of ANKS1B gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of ANKS1B mRNA24831965
D001280AtrazineAtrazine results in decreased expression of ANKS1B mRNA25929836
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C006780bisphenol Abisphenol A results in decreased expression of ANKS1B mRNA24586524
C006780bisphenol Abisphenol A results in increased methylation of ANKS1B gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of ANKS1B mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ANKS1B mRNA24982889
D003042CocaineCocaine results in decreased expression of ANKS1B mRNA17898221
D003471CuprizoneCuprizone results in decreased expression of ANKS1B mRNA26577399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ANKS1B mRNA27392435
D002945CisplatinCisplatin results in increased expression of ANKS1B mRNA27392435
C118739entinostatentinostat results in decreased expression of ANKS1B mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C540355fenamidonefenamidone results in decreased expression of ANKS1B mRNA27029645
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ANKS1B mRNA27392435
D008694MethamphetamineMethamphetamine results in decreased expression of ANKS1B mRNA26307267
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ANKS1B mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ANKS1B mRNA"20188158
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKS1B mRNA"27188386
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ANKS1B mRNA"25510870
C046012pentanalpentanal results in decreased expression of ANKS1B mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKS1B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANKS1B mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ANKS1B mRNA21061450
D011192Potassium DichromatePotassium Dichromate results in increased expression of ANKS1B mRNA23608068
D012293RifampinRifampin results in decreased expression of ANKS1B mRNA24552687
C017947sodium arsenitesodium arsenite affects the methylation of ANKS1B gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of ANKS1B mRNA27862939
D014212TretinoinTretinoin results in decreased expression of ANKS1B mRNA21934132
D014520UrethaneUrethane results in increased expression of ANKS1B mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ANKS1B mRNA28001369
C025643vinclozolinvinclozolin affects the expression of ANKS1B mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046875ephrin receptor binding-IPI17875921  
GO ID GO Term Qualifier Evidence PubMed
GO:1900383regulation of synaptic plasticity by receptor localization to synapse-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0014069postsynaptic density-IEA-  
GO:0015030Cajal body-IEA-  
GO:0030054cell junction-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24479813ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. (2014 Jan 31)Eckel-Passow JEBMC Urol
27533483Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population. (2017 Jan)Postula MPlatelets