Gene: SMCO4

56935
C11orf75|FN5
single-pass membrane protein with coiled-coil domains 4
protein-coding
11q21
Ensembl:ENSG00000166002 MIM:609477 Vega:OTTHUMG00000167442 UniprotKB:Q9NRQ5
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.726e-1 (AD)  9.286e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7126188chr11:93544100 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGST20.69
RNF1490.686
GTF2E20.682
SLC50A10.672
SNRPA0.665
BAX0.662
GLRX0.66
VKORC10.657
RASD10.649
COLGALT10.647

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.376
REN-0.368
OR4F5-0.368
OR4F29-0.364
ZNF98-0.356
DIO2-0.33
HPDL-0.323
PYGM-0.281
FAM180B-0.281
AQP6-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of SMCO4 mRNA"20453058
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMCO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMCO4 mRNA"27188386
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of SMCO4 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SMCO4 mRNA24449571
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMCO4 mRNA"19150397|2038263
D004958EstradiolEstradiol results in decreased expression of SMCO4 mRNA23019147
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SMCO4 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of SMCO4 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SMCO4 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of SMCO4 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of SMCO4 mRNA25270620
D019327Copper SulfateCopper Sulfate results in decreased expression of SMCO4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SMCO4 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of SMCO4 mRNA20106945
C014347decitabinedecitabine affects the expression of SMCO4 mRNA23300844
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SMCO4 mRNA]27941970
D002945CisplatinCisplatin affects the expression of SMCO4 mRNA23300844
D002945CisplatinCisplatin results in increased expression of SMCO4 mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of SMCO4 mRNA25016146
D004317DoxorubicinSMCO4 protein affects the susceptibility to Doxorubicin16217747
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMCO4 mRNA22079256
C546771gardiquimodgardiquimod results in increased expression of SMCO4 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SMCO4 mRNA]28003376
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SMCO4 mRNA25982114
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMCO4 mRNA"25554681
D009532NickelNickel results in decreased expression of SMCO4 mRNA23195993
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SMCO4 mRNA17097637
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMCO4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMCO4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SMCO4 mRNA22714537
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SMCO4 mRNA]28003376
D012822Silicon DioxideSilicon Dioxide results in increased expression of SMCO4 mRNA25351596
D013853ThioacetamideThioacetamide results in decreased expression of SMCO4 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of SMCO4 mRNA21934132|2372400
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMCO4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SMCO4 mRNA26272509
C057693troglitazonetroglitazone results in increased expression of SMCO4 mRNA28973697
D014520UrethaneUrethane results in decreased expression of SMCO4 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of SMCO4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SMCO4 mRNA25716160|2915479
D014638VanadatesVanadates results in decreased expression of SMCO4 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SMCO4 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of SMCO4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI21516116  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal