Gene: WDR18

57418
Ipi3|R32184_1
WD repeat domain 18
protein-coding
19p13.3
Ensembl:ENSG00000065268 Vega:OTTHUMG00000181903 UniprotKB:Q9BV38
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
4.167e-1 (AD)  8.768e-3 (ND)   (Frontal_Cortex)
4.866e-1 (AD)  5.141e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7249037chr19:988136 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26545040chr19:994110WDR181.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARFRP10.908
GPS10.903
TRMT2A0.898
E4F10.89
BRF10.89
ZNF4140.889
C21orf20.885
NCLN0.885
GPSM10.883
TRMT61A0.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.633
OR4F29-0.58
CXCR2-0.434
VNN2-0.428
KCNJ15-0.423
FCGR3B-0.421
PABPC4L-0.406
EBF1-0.393
ADH1B-0.389
MTRNR2L9-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of WDR18 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of WDR18 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WDR18 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of WDR18 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WDR18 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of WDR18 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of WDR18 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of WDR18 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of WDR18 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of WDR18 promoter22457795
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of WDR18 mRNA28472532
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of WDR18 mRNA20971185
C093628cyproconazolecyproconazole results in increased expression of WDR18 mRNA22334560
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of WDR18 mRNA21266533
C109476epoxiconazoleepoxiconazole results in increased expression of WDR18 mRNA22334560
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of WDR18 mRNA23649840
C007738fluoranthene[fluoranthene co-treated with pyrene] results in decreased expression of WDR18 mRNA20117838
D005485FlutamideFlutamide results in increased expression of WDR18 mRNA24136188
D005897GlafenineGlafenine results in increased expression of WDR18 mRNA24136188
C492448ICG 001ICG 001 results in increased expression of WDR18 mRNA26191083
C410337K 7174K 7174 results in decreased expression of WDR18 mRNA24086573
D008727MethotrexateWDR18 protein affects the susceptibility to Methotrexate16217747
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WDR18 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of WDR18 mRNA"20188158
C568376MT19c compoundMT19c compound results in decreased expression of WDR18 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of WDR18 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WDR18 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of WDR18 mRNA20971185
D010634PhenobarbitalPhenobarbital results in increased expression of WDR18 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of WDR18 mRNA23811191
C045950propiconazolepropiconazole results in increased expression of WDR18 mRNA21278054|2233456
C030984pyrene[fluoranthene co-treated with pyrene] results in decreased expression of WDR18 mRNA20117838
D053260SootSoot results in increased expression of WDR18 mRNA26551751
C004648testosterone enanthatetestosterone enanthate affects the expression of WDR18 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WDR18 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of WDR18 mRNA15894607
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of WDR18 mRNA19042947
D014520UrethaneUrethane results in decreased expression of WDR18 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of WDR18 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of WDR18 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21326211  
GO ID GO Term Qualifier Evidence PubMed
GO:0000027ribosomal large subunit assembly-IBA21873635  
GO:0006267pre-replicative complex assembly involved in nuclear cell cycle DNA replication-IBA21873635  
GO:0006364rRNA processing-IBA21873635  
GO:0006364rRNA processing-TAS-  
GO:0007275multicellular organism development-IEA-  
GO:0030174regulation of DNA-dependent DNA replication initiation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005656nuclear pre-replicative complex-IBA21873635  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0097344Rix1 complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal