Gene: TENM2

57451
ODZ2|TEN-M2|TNM2|ten-2
teneurin transmembrane protein 2
protein-coding
5q34
Ensembl:ENSG00000145934 MIM:610119 Vega:OTTHUMG00000162928 UniprotKB:Q9NT68
NC_000005.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.539e-1 (AD)  4.036e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1363204chr5:167893080 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM178B0.952
AMIGO10.935
FHOD30.934
SLITRK50.933
C11orf870.932
MYH100.932
KIAA1549L0.931
MYT1L0.93
ST6GALNAC50.929
SLC12A50.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.595
HEY2-0.594
RAI14-0.592
YES1-0.577
RAB13-0.574
REST-0.573
MYL3-0.572
GNG11-0.566
COPZ2-0.562
RNF135-0.558

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of TENM2 mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TENM2 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TENM2 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TENM2 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TENM2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TENM2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TENM2 mRNA16483693
D001151ArsenicArsenic affects the methylation of TENM2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of TENM2 mRNA20458559
C547126AZM551248AZM551248 results in decreased expression of TENM2 mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TENM2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TENM2 mRNA20106945
D004958EstradiolEstradiol affects the expression of TENM2 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of TENM2 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of TENM2 mRNA18007998
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of TENM2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TENM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TENM2 gene28505145
C026690cerous chloridecerous chloride results in increased expression of TENM2 mRNA23573234
D004390ChlorpyrifosChlorpyrifos results in decreased expression of TENM2 mRNA18668222
C031180chrysenechrysene results in increased expression of TENM2 mRNA26377693
D003042CocaineCocaine affects the expression of TENM2 mRNA20187946
D003042CocaineCocaine results in decreased expression of TENM2 mRNA17898221
D016572CyclosporineCyclosporine results in increased expression of TENM2 mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of TENM2 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of TENM2 mRNA25047013
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TENM2 gene23968726
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TENM2 mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TENM2 mRNA"22485181
D004317DoxorubicinDoxorubicin affects the methylation of TENM2 gene28962528
D005557FormaldehydeFormaldehyde results in increased expression of TENM2 mRNA23649840|2893796
C010178heliotrineheliotrine results in decreased expression of TENM2 mRNA26100227
C016517indole-3-carbinolindole-3-carbinol affects the expression of TENM2 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TENM2 mRNA24796395|2675264
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TENM2 mRNA28001369
C500085muraglitazarmuraglitazar results in increased expression of TENM2 mRNA21515302
D009966OrphenadrineOrphenadrine affects the expression of TENM2 mRNA23665939
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TENM2 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TENM2 mRNA26272509
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of TENM2 gene23968726
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TENM2 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TENM2 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TENM2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of TENM2 mRNA24780913
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of TENM2 mRNA26100227
C089730rosiglitazonerosiglitazone results in increased expression of TENM2 mRNA21515302
C009237senecioninesenecionine results in decreased expression of TENM2 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of TENM2 mRNA26100227
C017947sodium arsenitesodium arsenite affects the methylation of TENM2 gene28589171
C501413tesaglitazartesaglitazar results in increased expression of TENM2 mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of TENM2 mRNA26496021
D014112ToxapheneTENM2 gene SNP affects the susceptibility to Toxaphene25622337
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TENM2 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TENM2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TENM2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TENM2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TENM2 mRNA19101580|2317975
D014638VanadatesVanadates results in decreased expression of TENM2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TENM2 gene25560391
C025643vinclozolinvinclozolin affects the expression of TENM2 mRNA19015723
D014750VincristineVincristine results in increased expression of TENM2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0042803protein homodimerization activity-ISS-  
GO:0046982protein heterodimerization activity-IBA21873635  
GO:0046982protein heterodimerization activity-ISS-  
GO:0050839cell adhesion molecule binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0007165signal transduction-IEA-  
GO:0048666neuron development-IBA21873635  
GO:0051491positive regulation of filopodium assembly-ISS-  
GO:0097264self proteolysis-IEA-  
GO:0098609cell-cell adhesion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005794Golgi apparatus-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0016605PML body-ISS-  
GO:0030054cell junction-ISS-  
GO:0030175filopodium-ISS-  
GO:0030425dendrite-ISS-  
GO:0030426growth cone-ISS-  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-ISS-  
GO:0043197dendritic spine-ISS-  
GO:0045202synapse-ISS-  
GO:0045211postsynaptic membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal