Gene: NLN

57486
AGTBP|EP24.16|MEP|MOP
neurolysin
protein-coding
5q12.3
Ensembl:ENSG00000123213 MIM:611530 Vega:OTTHUMG00000097803 UniprotKB:Q9BYT8
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.335e-1 (AD)  6.546e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10940051chr5:65811762 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC10.928
CUL20.924
OPA10.923
IMPAD10.919
TRAPPC110.919
ZDHHC170.919
ANKRD13C0.917
HECTD10.917
TTC370.916
USP330.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.508
OR4F29-0.48
MTRNR2L6-0.438
CSAG1-0.415
MTRNR2L9-0.414
MTRNR2L10-0.403
MTRNR2L2-0.383
NKX6-1-0.371
MTRNR2L8-0.369
EVC2-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NLN mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NLN mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of NLN mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of NLN mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of NLN mRNA17562736
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NLN mRNA"23195993
D001280AtrazineAtrazine results in increased expression of NLN mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NLN mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NLN mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of NLN mRNA25181051
D002065BuspironeBuspirone results in decreased expression of NLN mRNA24136188
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of NLN mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of NLN mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of NLN mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NLN mRNA21266533
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NLN mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of NLN mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of NLN mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of NLN mRNA]19850644
C118739entinostatentinostat results in increased expression of NLN mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NLN mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of NLN mRNA23649840
D019833GenisteinESR1 promotes the reaction [Genistein results in decreased expression of NLN protein]20884965
D019833GenisteinGenistein results in decreased expression of NLN protein20884965
D017313FenretinideFenretinide results in decreased expression of NLN mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NLN mRNA25613284
C410337K 7174K 7174 results in increased expression of NLN mRNA24086573
D007649KetamineKetamine results in decreased expression of NLN mRNA20080153
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NLN mRNA26378955
C042720mercuric bromidemercuric bromide results in increased expression of NLN mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NLN mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NLN mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of NLN mRNA"26251327
D015741MetriboloneMetribolone results in increased expression of NLN protein17152098
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NLN mRNA"25620056
D009532NickelNickel results in decreased expression of NLN mRNA23195993
D009532NickelNickel results in increased expression of NLN mRNA24768652
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of NLN mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of NLN mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NLN protein26879310
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of NLN mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of NLN mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NLN mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of NLN mRNA17426115|1830175
D010936Plant ExtractsPlant Extracts results in increased expression of NLN mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of NLN mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of NLN protein28918527
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of NLN mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NLN mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NLN mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of NLN mRNA25729387
D014241TrichloroethyleneTrichloroethylene affects the expression of NLN mRNA21135412
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NLN gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NLN mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NLN mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of NLN mRNA22378314
D014520UrethaneUrethane results in decreased expression of NLN mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NLN mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NLN mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NLN gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NLN mRNA24383497|2627250
D014635Valproic AcidValproic Acid affects the expression of NLN mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of NLN mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IBA21873635  
GO:0004222metalloendopeptidase activity-TAS-  
GO:0042277peptide binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006111regulation of gluconeogenesis-IEA-  
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0006518peptide metabolic process-IBA21873635  
GO:1902809regulation of skeletal muscle fiber differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005758mitochondrial intermembrane space-IBA21873635  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04614Renin-angiotensin system
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal