Gene: GPR158

57512
-
G protein-coupled receptor 158
protein-coding
10p12.1
Ensembl:ENSG00000151025 MIM:614573 Vega:OTTHUMG00000017832 UniprotKB:Q5T848
NC_000010.11
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.613e-1 (AD)  9.880e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3005191chr10:25487247 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP7D20.974
SYNJ10.971
NRXN30.971
GABRG20.971
REEP10.97
PGM2L10.97
GDA0.97
RAB3C0.969
DCLK10.969
FAXC0.968

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.596
RNF135-0.576
MYL3-0.574
RAB13-0.574
COPZ2-0.569
HEY2-0.567
YES1-0.566
RHOD-0.565
CHST14-0.558
REST-0.551

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of GPR158 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GPR158 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of GPR158 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPR158 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPR158 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GPR158 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GPR158 gene27153756
C015001arsenitearsenite results in increased methylation of GPR158 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of GPR158 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of GPR158 mRNA25181051
D016572CyclosporineCyclosporine results in increased expression of GPR158 mRNA20106945
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GPR158 mRNA25613284
D011441PropylthiouracilPropylthiouracil results in decreased expression of GPR158 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPR158 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GPR158 mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of GPR158 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GPR158 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GPR158 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of GPR158 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GPR158 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GPR158 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0072659protein localization to plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer