Gene: UNC79

57578
KIAA1409
unc-79 homolog, NALCN channel complex subunit
protein-coding
14q32.12
Ensembl:ENSG00000133958 MIM:616884 Vega:OTTHUMG00000029783 UniprotKB:Q9P2D8
NG_051662.1
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.267e-1 (AD)  5.658e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12882384chr14:93519101 (GRCh38.p7)A>C / A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLGAP20.963
CSMD10.961
TANC20.954
DOCK30.95
DRP20.949
MYH100.949
KCNMA10.948
CACNA1B0.948
CACNA1D0.947
ADD20.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.566
HEY2-0.558
COPZ2-0.547
MYL3-0.529
YES1-0.524
SNHG18-0.524
EMP3-0.509
WWTR1-0.508
ROM1-0.507
CNN2-0.503

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of UNC79 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UNC79 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UNC79 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of UNC79 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UNC79 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of UNC79 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of UNC79 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of UNC79 gene28505145
D002994ClofibrateClofibrate results in increased expression of UNC79 mRNA23811191
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of UNC79 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of UNC79 mRNA22023808
C118739entinostatentinostat results in decreased expression of UNC79 mRNA27188386
C000625835HFPO2 compoundHFPO2 compound results in increased expression of UNC79 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of UNC79 mRNA27553808
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UNC79 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UNC79 mRNA"25620056
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of UNC79 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of UNC79 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of UNC79 mRNA25549359
D014520UrethaneUrethane results in increased expression of UNC79 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of UNC79 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of UNC79 gene29154799
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UNC79 mRNA"27188386
D015034Zinc OxideZinc Oxide analog results in decreased expression of UNC79 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0034220ion transmembrane transport-TAS-  
GO:0035264multicellular organism growth-IEA-  
GO:0048149behavioral response to ethanol-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal