Gene: NCOA5

57727
CIA|bA465L10.6
nuclear receptor coactivator 5
protein-coding
20q13.12
Ensembl:ENSG00000124160 MIM:616825 Vega:OTTHUMG00000032639 UniprotKB:Q9HCD5
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.540e-2 (AD)  4.368e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6074015chr20:46083536 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C2orf420.861
NXF10.861
RBM4B0.853
ZNF2020.847
UBTF0.834
ACIN10.83
DGCR80.829
SRSF60.826
EDC30.825
RBM100.824

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.601
OR4F29-0.572
RPE65-0.283
SLC2A4-0.273
PLA2G3-0.26
KLRB1-0.223
ARHGAP8-0.222
C9orf153-0.217
TIGIT-0.216
IL18RAP-0.214

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB07702(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOLSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of NCOA5 mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NCOA5 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of NCOA5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NCOA5 mRNA19770486
D000450Aldosterone[Aldosterone binds to NR3C2 protein] which binds to NCOA5 protein15761029
D001280AtrazineAtrazine results in decreased expression of NCOA5 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of NCOA5 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of NCOA5 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NCOA5 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOA5 mRNA"19150397|2038263
C006780bisphenol Abisphenol A results in decreased expression of NCOA5 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of NCOA5 protein28903499
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCOA5 gene20938992
D016572CyclosporineCyclosporine results in decreased expression of NCOA5 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of NCOA5 mRNA23640034
D004026DieldrinDieldrin results in increased expression of NCOA5 mRNA20438755
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of NCOA5 mRNA27638505
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NCOA5 protein23301498
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCOA5 gene20938992
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of NCOA5 mRNA22634610
D007854LeadLead affects the expression of NCOA5 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of NCOA5 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCOA5 gene20938992
D008727MethotrexateMethotrexate affects the expression of NCOA5 mRNA18502557
C030589methylmercury cysteinemethylmercury cysteine results in decreased expression of NCOA5 mRNA19465457
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NCOA5 mRNA24810058
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of NCOA5 mRNA"29244179
C028007nickel monoxidenickel monoxide results in increased expression of NCOA5 mRNA19167457
D010100OxygenOxygen deficiency results in decreased expression of NCOA5 mRNA24236059
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of NCOA5 mRNA19095052
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NCOA5 protein26879310
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NCOA5 mRNA19710929
C059514resveratrolresveratrol results in decreased expression of NCOA5 protein25505154
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of NCOA5 mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NCOA5 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NCOA5 mRNA21570461
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NCOA5 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of NCOA5 mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of NCOA5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NCOA5 mRNA19101580|2915479
D014635Valproic AcidValproic Acid results in decreased methylation of NCOA5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NCOA5 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of NCOA5 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of NCOA5 mRNA20546886|2142705
D014635Valproic AcidValproic Acid results in increased expression of NCOA5 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NCOA5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI11113208  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0046627negative regulation of insulin receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005634nucleus-IDA-  
GO:0015629actin cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal