Gene: ZNF462

58499
Zfp462
zinc finger protein 462
protein-coding
9q31.2
Ensembl:ENSG00000148143 MIM:617371 Vega:OTTHUMG00000020438 UniprotKB:Q96JM2
NG_052913.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.694e-1 (AD)  7.399e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17787921chr9:106869544 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFHX40.787
SRGAP10.755
PLEKHA70.735
NHSL10.732
CHD70.729
TRPS10.722
TET10.706
KANK10.706
PAFAH20.701
CECR20.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BHLHA9-0.421
AP1M2-0.417
CACNA1F-0.395
MCHR1-0.382
NELL1-0.367
LRRC38-0.358
PHOSPHO1-0.354
RTBDN-0.352
RTP1-0.351
QRFPR-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF462 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF462 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZNF462 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZNF462 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of ZNF462 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZNF462 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZNF462 mRNA20064835|2231617
C018021cobaltous chloridecobaltous chloride results in decreased expression of ZNF462 mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of ZNF462 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased methylation of ZNF462 promoter27989131
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF462 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ZNF462 mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of ZNF462 mRNA21852083
D002117CalcitriolCalcitriol results in increased expression of ZNF462 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ZNF462 mRNA21592394
D017313FenretinideFenretinide results in increased expression of ZNF462 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ZNF462 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZNF462 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF462 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ZNF462 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of ZNF462 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ZNF462 mRNA]26733615
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ZNF462 mRNA]26733615
D008777MethyltestosteroneMethyltestosterone results in increased expression of ZNF462 mRNA29191790
D009532NickelNickel results in decreased expression of ZNF462 mRNA25583101
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ZNF462 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of ZNF462 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ZNF462 mRNA]26733615
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of ZNF462 mRNA21852083
D012293RifampinRifampin results in decreased expression of ZNF462 mRNA24552687
D012906SmokeSmoke results in decreased expression of ZNF462 mRNA21095227
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ZNF462 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ZNF462 mRNA21592394
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZNF462 mRNA25613284
C012589trichostatin Atrichostatin A results in decreased expression of ZNF462 mRNA15901671
D014415TunicamycinTunicamycin results in decreased expression of ZNF462 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZNF462 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ZNF462 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZNF462 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased expression of ZNF462 mRNA15901671
D024483Vitamin K 3Vitamin K 3 affects the expression of ZNF462 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI27705803  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0010468regulation of gene expression-IBA21873635  
GO:0016569covalent chromatin modification-IBA21873635  
GO:0031060regulation of histone methylation-IBA21873635  
GO:0043392negative regulation of DNA binding-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleusCOLOCALIZES_WITHIBA21873635  
GO:0005634nucleus-IEA-  
GO:0035097histone methyltransferase complexCOLOCALIZES_WITHIBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal